Author

M. Hosmillo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:human· 5 Assay:proteomics· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2

Frequent Co-Authors

I. G. Goodfellow· 4 shared I. Goodfellow· 4 shared E. Emmott· 3 shared R. Doffinger· 3 shared A. S. Jahun· 2 shared F. Sorgeloos· 2 shared Y. Chaudhry· 2 shared A. Abdullahi· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

I. G. Goodfellow

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Porcine sapovirus protease controls the innate immune response and targets TBK1

I. Georgana, M. Hosmillo, A. S. Jahun, E. Emmott, F. Sorgeloos, K.-O. Cho, I. G. Goodfellow

This study shows that the porcine sapovirus protease NS6 inhibits type I IFN production by targeting TBK1, revealing a mechanism for immune evasion and establishing a new cell line model for PSaV research.

bioRxiv · Dec 21, 2023Microbiology

Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD-20 therapy

A. Priddey, M. X. H. Chen-Xu, D. J. Cooper, S. MacMillan, G. Meisl, C. K. Xu, M. Hosmillo, I. G. Goodfellow, R. Kollyfas, R. Doffinger, J. R. Bradley, I. I. Mohorianu, R. Jones, T. P. J. Knowles, R. Smith, V. Kosmoliaptsis

bioRxiv · Oct 22, 2023Immunology

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

B. Meng, I. Ferreira, A. Abdullahi, N. Goonawardane, A. Saito, I. Kimura, D. Yamasoba, S. A. Kemp, G. Papa, S. Fatihi, S. Rathore, P. Perera Gerba, T. Ikeda, M. Toyoda, T. S. Tan, , S. Zepeda

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

bioRxiv · Dec 17, 2021Microbiology

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

L. G. Thorne, M. Bouhaddou, A.-K. Reuschl, L. Zuliani-Alvarez, B. J. Polacco, A. Pelin, J. Batra, M. V. X. Whelan, M. Ummadi, A. Roic, J. Turner, K. Obernier, H. Braberg, M. Soucheray, A. L. Richards, , N. J. Krogan

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology

A thermostable, closed, SARS-CoV-2 spike protein trimer.

X. Xiong, K. Qu, K. A. Ciazynska, M. Hosmillo, A. P. Carter, S. Ebrahimi, Z. Ke, S. H. W. Scheres, L. Bergamaschi, G. L. Grice, Y. Zhang, The CITIID-NIHR COVID-19 BioResource Collaboration, J. A. Nathan, S. Baker, L. C. James, , J. A. G. Briggs

This paper designs a thermostable, closed SARS-CoV-2 spike protein trimer that remains in the pre-fusion state and can be used in serological assays.

bioRxiv · Jun 15, 2020Biochemistry

Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells.

H. V. Mears, E. Emmott, Y. Chaudhry, M. Hosmillo, I. G. Goodfellow, T. R. Sweeney

This study shows Ifit1 enhances the interferon response but does not directly inhibit norovirus translation in murine macrophage-like cells.

bioRxiv · Apr 17, 2019Immunology

Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation.

M. Hosmillo, J. Lu, M. R. McAllaster, J. B. Eaglesham, X. Wang, E. Emmott, P. Domingues, Y. Chaudhry, T. J. Fitzmaurice, M. K. H. Tung, M. Panas, G. McInerney, N. Locker, C. B. Willen, I. Goodfellow

This study identifies G3BP1 as a host factor essential for norovirus infection and reveals its role in VPg-dependent translation initiation.

bioRxiv · Mar 8, 2019Microbiology

A robust human norovirus replication model in zebrafish larvae

J. Van Dycke, A. Ny, N. Conceicao-Neto, J. Maes, M. Hosmillo, A. Cuvry, I. Goodfellow, T. C. de Araujo Nogueira, E. Verbeken, J. Matthijnssens, P. de Witte, J. Neyts, J. Rocha-Pereira

This study establishes a zebrafish larval model for human norovirus replication, showing high viral titers and antiviral response potential.

bioRxiv · Jan 23, 2019Microbiology

Epigenetic suppression of interferon lambda receptor expression leads to enhanced HuNoV replication in vitro

S. E. Arthur, F. Sorgeloos, M. Hosmillo, I. Goodfellow

This study identifies epigenetic suppression of IFNLR1 as a mechanism enhancing HuNoV replication in vitro by reducing antiviral interferon lambda signaling.

bioRxiv · Jan 21, 2019Microbiology