N. Li

This study examines the impact of early antibiotic use on the gut microbiome, metabolome, and inflammatory environment in preterm infants through a randomized trial.

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

This study identifies a leucine-derived fatty acid and glycosphingolipid that mediate amino acid sensing by mTORC1 in C. elegans, regulating development through protein translation and ribosomal biogenesis.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This paper introduces PIC-IT, a photoconversion-based technique to isolate spatially distinct tumor cells, revealing phenotypic heterogeneity and NF-κB/AP-1 signaling enrichment in disseminated tumor cells.

This study shows that IgT is the main immunoglobulin induced in trout skin mucosa during bacterial infection, with SALT serving as a key inductive site.

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

The paper shows that the SUMO system regulates TOC complex stability and chloroplast development in Arabidopsis by stabilizing TOC proteins.

This study shows BNP treatment enhances vascularization and endothelial cell proliferation in infarcted hearts, with effects on both resident endothelial cells and WT1+ epicardium-derived cells.

This study compares fecal metabolites in preterm infants exposed to antibiotics versus those not exposed within the first 48 hours after birth, finding significant differences in metabolic pathways.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study demonstrates that targeted enzyme replacement therapy using antibody-enzyme fusion proteins improves skeletal muscle phenotypes in Pompe disease mice compared to standard enzyme replacement therapy.

This study investigates bidirectional crosstalk between HIF and glucocorticoid signaling in zebrafish larvae, revealing how hypoxia and glucocorticoids influence each other in vivo.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

This study analyzes HTNV genetic diversity and evolution in China and neighboring regions, identifying phylogroups, recombination events, and geographic clustering patterns.

This paper introduces a DNA-based fluorescent probe, DNAMeter, to quantify intercellular tensile forces through real-time imaging and fluorescence signal activation.

This study evaluates the histologic safety of transcranial focused ultrasound neuromodulation and MR-ARFI in rhesus macaques and sheep, finding no FUS-related tissue damage.

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.

This study identifies a chitinase gene from Chinese wildrye that enhances pathogen resistance and saline-alkali stress tolerance in transgenic tobacco and maize without affecting growth.

This study identifies DSCAM-AS1 as a promoter of breast cancer growth by downregulating miR-204-5p and upregulating RRM2, suggesting it as a potential therapeutic target.

This study shows MITA regulates BCR signaling through actin reorganization via the PI3K pathway, affecting B cell differentiation and autoimmune disease.

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.