N. Li

The paper uses cryo-EM and a new segmentation method to reveal the early assembly pathway of bacterial ribosome large subunit, identifying cooperative blocks and a unified maturation landscape.

The paper was withdrawn due to duplicate posting and is no longer available for citation.

This study shows vaccine boosting of CAR T-cells enhances tumor eradication by promoting antigen spreading and endogenous T-cell engagement, even in antigen-negative tumors.

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

The study identifies CsFLC1 in tea plants, showing it influences flowering and bud dormancy, and demonstrates its function in Arabidopsis by promoting early flowering and affecting gene expression related to flowering and hormone pathways.

This study identifies NOTUM as a therapeutic target in advanced colorectal cancer, showing that its inhibition effectively arrests tumor growth and metastasis in models with APC and P53 mutations.

This study develops esterase-resistant and highly active ghrelin analogs using thiol-ene click chemistry, showing improved stability and activity in serum.

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

This study shows Streptococcus pneumoniae promotes lung tumorigenesis by activating PI3K/AKT and NF-kB pathways through PspC-PAFR binding in lung cancer cells.

This paper reports chromosome-level genome assemblies of five Sitopsis species and identifies the B-subgenome donor of bread wheat as an extinct species closely related to Ae. speltoides.

COSMOS enables real-time, unlabeled cell sorting based on morphology using deep learning, achieving high enrichment of viable cells for functional analysis.

The paper develops improved fluorescent proteins for dual-color post-embedding CLEM, enhancing signal-to-background ratio and reducing autofluorescence background.

This study investigates how homoeologous exchange affects gene expression and alternative splicing in synthetic allotetraploid wheat, finding cis- and trans-regulatory impacts on gene expression and AS events.

The paper uses patient-derived iPS cells to model liver pathologies in telomeropathies and identifies AKT suppression as a potential therapeutic target.

This study shows NtrX regulates CtrA signaling network genes in S. meliloti, affecting cell division and linking nitrogen metabolism to cell cycle control.

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

This study evaluates the effect of Idesia polycarpa fruit residues fermented feed additive on laying quail egg production and related performance metrics, finding improved egg production, reduced cholesterol, and enhanced lipid metabolism.

This study identifies a pyroptosis-related molecular classification and prognostic signature for glioma using integrative analysis of genomic and clinical data.

This study induces human adipose-derived mesenchymal stem cells into hepatocyte-like cells using small-molecule cocktails and growth factors, producing cells with mature phenotype and function.

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

This study isolates and characterizes three phages targeting MDR Klebsiella pneumoniae isolates, showing their lytic potential but also the emergence of phage-resistant mutants.

This study shows that BiTE-secreting T cells outperform CAR T cells in killing glioma cells in vitro and in vivo, with enhanced cytotoxicity and tumor growth delay.

The paper identifies a lipid-mTORC1 pathway regulated by peroxisome-derived hormones that controls development in C. elegans by modulating chemosensory neurons.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.