Author

P. A. Futreal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

A. G. X. Zeng· 1 shared A. Hayes-Jordan· 1 shared A. J. Lazar· 1 shared A. M. Vetter· 1 shared A. Mitchell· 1 shared A. R. MacLeod· 1 shared A. R. Velasco· 1 shared A. Tierens· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. G. X. Zeng

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3 papers

Recent·Most cited

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AML

A. G. X. Zeng, S. Bansal, L. Jin, A. Mitchell, W. C. Chen, H. A. Abbas, M. Chan-Seng-Yue, V. Voisin, P. van Galen, A. Tierens, M. Cheok, C. Preudhomme, H. Dombret, N. Daver, P. A. Futreal, , J. E. Dick

This study identifies a cellular hierarchy framework in AML that links disease heterogeneity with drug response and develops a 7-gene biomarker predictive of drug sensitivity.

bioRxiv · Jan 25, 2022Cancer Biology

The Androgen Receptor: A Therapeutic Target in Desmoplastic Small Round Cell Sarcoma

S.-E. Lamhamedi-Cherradi, M. Maitituoheti, B. A. Menegaz, S. Krishnan, A. M. Vetter, P. Camacho, C.-C. Wu, H. C. Beird, R. W. Porter, D. R. Ingram, V. Ramamoorthy, S. Mohiuddin, D. McCall, D. D. Truong, B. Cuglievan, , J. A. Ludwig

The paper shows that DSRCT is driven by the androgen receptor and responds to androgen deprivation therapy.

bioRxiv · Jan 20, 2022Cancer Biology

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics

K. Morita, F. Wang, K. Jahn, J. Kuipers, Y. Yan, J. Matthews, L. Little, C. Gumbs, S. Chen, J. Zhang, X. Song, E. Thompson, K. Patel, C. Bueso-Ramos, C. D. DiNardo, , K. Takahashi

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

bioRxiv · Feb 7, 2020Cancer Biology