P. Gong

The interferon/STAT1 signaling axis is a common feature of tumor-initiating cells in breast cancer

The paper identifies an IFN/STAT1 transcriptional state in tumor-initiating cells (TIC) of breast cancer using single-cell RNA sequencing, showing it differs from bulk RNA-seq derived TIC signatures.

Migratory herbivorous waterfowl track multiple resource waves during spring migration

This study shows East Asian herbivorous waterfowl use both seed and green waves during spring migration, with species-specific strategies depending on body size and location.

A cataract-causing Y204X mutation of CRYβB1 promotes C-terminal degradation and higher-order oligomerization

This study identifies a cataract-causing mutation in CRYβB1 that leads to C-terminal truncation, increased proteolysis, and higher-order oligomerization, contributing to lens opacity.

Segmented MS/MS acquisition of a1 ion-based strategy for in-depth proteome quantitation

The paper introduces deep-APQ, a proteome quantitation method using segmented MS/MS acquisition of a1 ions, showing improved coverage and accuracy in E. coli proteome analysis.

Modulation of the DA1 pathway in maize shows that translatability of information from Arabidopsis to crops is complex

The paper investigates the DA1 pathway in maize to assess if findings from Arabidopsis can be translated, finding limited organ size changes in mutants.

AHR agonist ITE boosted PD1 antibodys effects by inhibiting myeloid-derived cells suppressive cells in an orthotopic mouse glioma model

The paper shows that ITE, an AHR agonist, enhances PD1 antibody efficacy in a glioma model by reducing MDSCs and increasing CD8+ T cell infiltration.

SAMBA controls the rate of cell division in maize development through APC/C interaction

This study shows that SAMBA regulates cell division rate in maize by interacting with APC/C, with different alleles causing varying growth defects due to altered protein function.

Geminiviral genomes encode additional proteins with specific subcellular localizations and virulence function

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.

Targeting Aryl Hydrocarbon Receptor with small molecule, 1'H-indole-3'-carbonyl -thiazole-4-carboxylic acid methyl ester blocked human glioma cell invasion via MYH9

The paper shows that ITE, an AHR ligand, inhibits glioma cell migration and invasion by reducing MYH9 expression, which is critical for cell motility.

sgRNA level is a major factor affecting CRISPRi knockdown efficiency in K562 cells

This study shows that sgRNA expression level is a major determinant of CRISPRi knockdown efficiency in K562 cells, more impactful than KRAB-dCas9 expression level.

Semaphorin 3a reduces the side effects of radiation on BMSCs by reducing ROS

This study shows that Sema3a reduces radiation-induced ROS levels and mitigates adverse effects on BMSCs by improving osteogenic differentiation and reducing adipogenic differentiation and inflammation.