T. Fan

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

Landscape and functional repertoires of long noncoding RNAs in the pan-cancer tumor microenvironment using single-nucleus total RNA sequencing

The paper maps lncRNA landscapes across ten cancer types using single-nucleus RNA sequencing and identifies cell type-specific lncRNA-mRNA pairs and regulatory networks.

FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway

This study shows FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway by interacting with FLU and inactivating GluTR.

Lung Epithelial Cells Can Produce Antibodies Participating In Adaptive Humoral Immune Responses

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity

The paper identifies PD-L1-lncRNA, a long non-coding RNA splice variant of PD-L1, that promotes lung adenocarcinoma progression by enhancing c-Myc activity.

Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

This paper describes a saliva-based SARS-CoV-2 testing method that avoids RNA extraction, achieving a detection limit comparable to nasal swabs and showing good performance with clinical samples.

Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

Autophagy Decreases Alveolar Epithelial Cell Injury by Suppressing the NF-κB Signaling Pathway and Regulating the Release of Inflammatory Mediators

This study shows that autophagy reduces lung injury by inhibiting the NF-κB pathway and inflammatory mediator release in hypoxia models.

Knockdown of GAS5 restores ox-LDL-induced impaired autophagy flux via upregulating miR-26a in human endothelial cells

This study shows that knocking down GAS5 restores ox-LDL-induced autophagy dysfunction in endothelial cells by upregulating miR-26a.