Author

R. Craigie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

M. Li· 3 shared A. Biswas· 2 shared D. Lyumkis· 2 shared D. Passos· 2 shared M. Kvaratskhelia· 2 shared Z. Li· 2 shared Z. Shan· 2 shared A. Haldane· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersBiochemistry

M. Li

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

T. Jing, Z. Shan, T. Dinh, A. Biswas, S. Jang, J. Greenwood, M. Li, Z. Zhang, G. Gray, H. J. Shin, B. Zhou, D. Passos, T. S. Strutzenberg, S. Aiyer, L. Andrade, , D. Lyumkis

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

bioRxiv · Jan 26, 2024 · PreprintBiochemistry

Mechanisms of HIV-1 Integrase Resistance to Dolutegravir and Potent Inhibition of Drug Resistant Variants

M. Li, D. Passos, Z. Shan, S. J. Smith, Q. Sun, A. Biswas, I. Choudhuri, T. Strutzenberg, A. Haldane, N. Deng, Z. Li, X.-Z. Zhao, T. R. Burke, R. M. Levy, S. H. Hughes, , D. Lyumkis

The paper investigates mechanisms of HIV-1 integrase resistance to Dolutegravir and shows that 4d is more effective against resistant variants.

bioRxiv · Dec 4, 2022Biophysics

HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification

N. E. Sapp, N. Burge, K. Cox, S. Thapa, P. Prakash, M. Balasubramaniam, D. Christensen, M. Li, J. Linderberger, M. Kvaratskhelia, W. I. Sundquist, J. Pandhare, R. Craigie, M. G. Poirier, C. Dash

This study identifies that HIV-1 preintegration complex preferentially integrates viral DNA into nucleosomes with H3K36me3 modification and linker DNA.

bioRxiv · Feb 16, 2022 · PreprintBiochemistry