Author

R. P. Sebra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Charap· 1 shared A. Charney· 1 shared A. M. Farkas· 1 shared A. O. Kamphorst· 1 shared A. Peres· 1 shared A. S. Walker· 1 shared A. T. M. Hubbard· 1 shared B. Lee· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

A. Charap

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

FLAIRR-seq: A novel method for single molecule resolution of near full-length immunoglobulin heavy chain repertoires

E. E. Ford, D. Tieri, O. L. Rodriguez, N. J. Francoeur, J. Soto, J. T. Kos, A. Peres, W. S. Gibson, C. A. Silver, G. Deikus, E. Hudson, C. R. Woolley, N. Beckmann, A. Charney, T. C. Mitchell, , M. L. Smith

FLAIRR-seq provides high-resolution, single-molecule characterization of immunoglobulin heavy chain repertoires, including constant region features, and identifies novel alleles.

bioRxiv · Sep 24, 2022 · PreprintImmunology

NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer

B. Salome, J. P. Sfakianos, J. Daza, A. Charap, C. Hammer, R. Banchereau, A. M. Farkas, D. Geanon, G. Kelly, R. M. de Real, B. Lee, K. G. Beaumont, S. Shroff, Y. S. A. Wang, Y.-C. Wang, , Mariath

This study identifies NKG2A and HLA-E as an alternative immune checkpoint axis in bladder cancer, showing NKG2A+ CD8 T cells can bypass HLA-ABC loss through TCR-independent cytotoxicity.

bioRxiv · Mar 4, 2022 · PreprintImmunology

The impact of sequencing depth on the inferred taxonomic composition and AMR gene content of metagenomic samples

H. S. Gweon, L. P. Shaw, J. Swann, N. De Maio, M. AbuOun, A. T. M. Hubbard, M. J. Bowes, M. J. Bailey, T. E. A. Peto, S. J. Hoosdally, A. S. Walker, R. P. Sebra, D. W. Crook, M. Anjum, D. S. Read, , The REHAB consortium

This study evaluates how sequencing depth affects taxonomic composition and AMR gene detection in metagenomic samples, finding that higher depth is needed for AMR gene richness.

bioRxiv · Mar 31, 2019Microbiology

Reconstitution of eukaryotic chromosomes and manipulation of DNA N6-methyladenine alters chromatin and gene expression

L. Y. Beh, G. T. Debelouchina, D. M. Clay, R. E. Thompson, K. A. Lindblad, E. R. Hutton, J. R. Bracht, R. P. Sebra, T. W. Muir, L. F. Landweber

This study identifies a novel DNA 6mA methyltransferase in ciliates and shows 6mA affects chromatin organization and gene expression.

bioRxiv · Nov 20, 2018 · PreprintBiochemistry

Parallel evolution of two clades of a major Atlantic endemic Vibrio parahaemolyticus pathogen lineage by independent acquisition of related pathogenicity islands

F. Xu, N. Gonzalez-Escalona, K. P. Drees, R. P. Sebra, V. S. Cooper, S. H. Jones, C. A. Whistler

The paper investigates how two clades of Vibrio parahaemolyticus evolved independently through acquisition of distinct pathogenicity islands, contributing to increased infections in the Northeast US.

bioRxiv · Jun 28, 2017Evolutionary Biology