R. Sharma

The paper identifies age-related thymic epithelial cell states that impair thymic regeneration and immune function through spatial and single-cell transcriptomics.

This study shows that CXCR4+ Treg cells regulate B1 cell accumulation in the bone marrow, leading to control of IgM autoantibody production and serum IgM levels.

A tomato trifoliate allele encoding a truncated MYB117 transcription factor alters cellular homeostasis and fortifies γ-aminobutyric acid, folate, and carotenoids in tomato fruits.

The paper investigates the function and recognition mechanism of M. tuberculosis ESX-1 virulence factor EspC and its interaction with EccA1 ATPase, identifying key binding regions and their impact on secretion.

This study uses machine learning to predict C. elegans olfactory behavior from odorant chemical structures, achieving human-level accuracy and revealing a non-trivial relationship between molecular features and behavior.

The paper shows that PSY2 contributes to abscisic acid formation in ripening tomato fruits by maintaining a parallel carotenogenesis pathway when PSY1 is absent.

This study determines the cryo-EM structure of SidJ in complex with SdeA, revealing its mechanism of glutamylation and substrate recognition.

This paper develops flexible polyimide-based electrodes with IrOx for interfacing mouse vagus nerve, showing stable performance and efficacy in stimulating physiological responses.

This study reveals high intratumoral heterogeneity in pancreatic cancer cell lines and highlights issues with reproducibility and validity of preclinical models.

This study shows tomato roots sense horizontal/vertical mechanical impedance and modulate metabolite profiles differently in roots and shoots.

The paper identifies the Caprin-1 interactome under unstressed and stressed conditions, revealing novel components of stress granules and their association with ALS aggregates.

The paper models CRISPR gene drives for rodent population suppression and finds they can eliminate island populations if resistance is minimized.

A dominant-negative mutation in phototropin1 increases carotenoid content and alters metabolite and protein profiles in tomato fruits.

The paper investigates the dynamic multi-OMICs of glioblastoma and identifies sensitivity to neddylation inhibition, though the manuscript was withdrawn due to un reproducible findings.

This study identifies the origin of photoperiod non-responsiveness in barley by analyzing genetic variation and haplotype relationships in wild and domesticated barleys.

This paper develops a rapid colorimetric assay for detecting SARS-CoV-2 RNA in clinical samples with high sensitivity and specificity.

This study identifies ACS2's role in tomato development beyond fruit ripening by analyzing two contrasting acs2 mutants and their phenotypic and metabolomic differences.

The paper tests a novel pollen transformation method in monocots and finds no evidence of successful transient transformation in maize and sorghum.

This study investigates hormonal and metabolic responses in Pongamia pinnata under salinity stress, revealing key adaptations that confer salt tolerance.

This study analyzes SARS-CoV-2 genomes from global isolates to reveal mosaic phylogeographical patterns and identify unique mutations associated with immune evasion mechanisms.

This study shows that deletion of RsmE in Mycobacterium smegmatis increases aminoglycoside resistance by altering 16S rRNA methylation, highlighting RsmE's role in drug resistance.

This study identifies structural instability and divergence from conserved residues as causes of intracellular retention of odorant receptors, using computational and experimental methods.

This paper describes how to incorporate genetic selection into individual-based models of infectious diseases, identifying strategies and recommendations for simulating mutation spread and control effectiveness.

This study identifies distinct protein-protein interactions of the residual SWI/SNF complex in SMARCA4-deficient SCCOHT cell lines, revealing altered functional consequences and potential synthetic lethal targets.

This paper develops an Agrobacterium-mediated transient transformation method for sorghum leaves to efficiently test vector constructs and genome editing tools.

This study compares in vitro Reactive Accelerated Aging of Parylene-C coated Utah arrays to in vivo degradation over 3.25 years in feline nerve, finding similar physical damage but distinct chemical changes.

The paper investigates the relationship between polar auxin transport and glutathione levels in tomato mutant pct1-2, finding that GSH levels influence PAT and root elongation.

This study shows PTX3 suppresses Th17 responses and increases susceptibility to Leishmania major infection by inhibiting IL-17A production and Th17-specific transcription factors.

This paper develops a portable 2D gas chromatography device with machine learning to diagnose ARDS from breath samples, achieving 87.1% accuracy.

The paper shows that Pseudozyma yeasts retain effector proteins, including Pep1 orthologs, which can restore virulence in a Ustilago maydis mutant, suggesting potential plant pathogenic capabilities.