Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.
D. H. Siepe, L. T. Henneberg, S. C. Wilson, G. T. Hess, M. C. Bassik, K. Zinn, K. C. Garcia
The paper develops a CRISPRa-based screening platform to identify orphan ligand-receptor interactions by screening secreted proteins against cell surface receptor libraries.
bioRxiv · Jun 22, 2022Cell Biology