S. O'Keefe

Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: The METS-Microbiome Study

This study examines how gut microbiota, short chain fatty acids (SCFAs), and obesity vary by country of origin and adiposity in a large African-origin cohort, finding significant differences in microbial composition and SCFA levels across populations.

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

This study shows that circadian-regulated endocytic recycling is essential for collagen fibril assembly and is disrupted in fibrosis.

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

This study shows that ipomoeassin F inhibits the ER membrane translocation of SARS-CoV-2 spike, ORF8, and ACE2 proteins in vitro.

The neoantigen landscape of mycosis fungoides

This study characterizes the neoantigen landscape in mycosis fungoides, finding high mutational load and neoantigen diversity, but also significant subclonality and patient-specific heterogeneity.

Independent evolution of cutaneous lymphoma subclones in different microenvironments of the skin

This study shows that cutaneous lymphoma subclones evolve independently in different skin microenvironments, leading to ecological heterogeneity and intratumoral heterogeneity.

Branched evolution and genomic intratumor heterogeneity in the pathogenesis of cutaneous T-cell lymphoma

This study identifies branched evolutionary patterns and intratumoral heterogeneity in mycosis fungoides, revealing complex clonal substructures and their implications for treatment resistance.

Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma

This study identifies multiple neoplastic T-cell clones in MF lesions and peripheral blood, suggesting they continuously replenish lesions and contribute to tumor heterogeneity.