T. Qiu

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

This study identifies potent and broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from a vaccinated donor, showing their efficacy against multiple variants and providing insights for therapeutic development.

Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression.

This study shows that NAT10 loss reduces lung metastasis by disrupting enhancer organization through p300 mislocalization and altering gene transcription related to metastasis.

Cell Type Specific Responses of the Endoplasmic Reticulum Dynamics to Environmental Stress

This study develops a super-resolution imaging and analysis method to study ER dynamics in Arabidopsis under environmental stress, revealing correlations between ER structure parameters and growth features.

Therapeutic targeting of KRAS mutation-driven tumorigenesis by extracellular vesicles loaded with small interfering RNA

This study demonstrates that extracellular vesicles loaded with KRAS-targeting siRNA can inhibit tumor growth in mouse models, both intratumorally and intravenously.

Harnessing extracellular vesicles for efficient siRNA delivery in vitro and in vivo

This study develops an efficient siRNA delivery system using extracellular vesicles, demonstrating effective gene silencing in vitro and tumor growth inhibition in vivo.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

Regulation of ERK2 activity by dynamic S-acylation

This study identifies S-acylation as a regulatory mechanism for ERK1/2 activity, showing its modulation by EGF signaling and its impact on transcriptional programs and metabolic health.

The genomic landscape of metastasis in treatment-naive breast cancer models

This study identifies recurrent mutations and copy number variations as key drivers of metastasis in treatment-naive breast cancer using pre-clinical mouse models.