Author

L. Qu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 2 Biochemistry· 1 Biophysics· 1 Ecology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Approach:microscopy & imaging analysis· 3 Organism:mouse· 3 Research Focus:benchmarking· 2 Research Focus:clustering· 2 Approach:deep learning· 2 Research Focus:dimensionality reduction· 2

Frequent Co-Authors

F. Wang· 2 shared H. Dai· 2 shared H. Li· 2 shared H. Mao· 2 shared J. Tan· 2 shared L. Chen· 2 shared S. Zhao· 2 shared W. Zhao· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

F. Wang

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Author profile →

9 papers

Recent·Most cited

Self-inspired learning to denoise for live-cell super-resolution microscopy

L. Qu, S. Zhao, Y. Huang, X. Ye, K. Wang, Y. Liu, X. Liu, H. Mao, G. Hu, W. Chen, C. Guo, J. He, J. Tan, H. Li, L. Chen, W. Zhao

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

bioRxiv · Jan 23, 2024Bioengineering

Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation

W. Zhao, X. Huang, J. Yang, G. Qiu, L. Qu, Y. Zhao, S. Zhao, Z. Luo, X. Wang, Y. Jiu, H. Mao, X. Ding, J. Tan, Y. Hu, L. Pan, , H. Li

This paper introduces a method to quantitatively map the local quality of super-resolution microscopy images, enabling better integration of reconstructions and detection of uncertainties.

bioRxiv · Dec 1, 2022Biophysics

Tree and shrub richness modify subtropical tree productivity by modulating the diversity and community composition of soil bacteria and archaea

S. Tao, G. F. C. Veen, T. Yu, N. Zhang, L. Qu

The paper examines how tree and shrub richness affects tree productivity by altering soil bacterial and archaeal diversity and composition in a subtropical forest experiment.

bioRxiv · Jul 30, 2022 · PreprintEcology

Non-Invasive Confocal Fluorescence Imaging of Mice Beyond 1700 nm Using Superconducting Nanowire Single-Photon Detectors

F. Wang, F. Ren, Z. Ma, L. Qu, R. Gourgues, C. Xu, A. Baghdasaryan, J. Li, I. E. Zadeh, J. W. Los, A. Fognini, J. Qin-Dregely, H. Dai

This paper develops a non-invasive imaging technique using NIR-IIc light to image deep tissues in mice, achieving imaging depths of ~800 m and visualizing immune structures in lymph nodes.

bioRxiv · Aug 13, 2021 · PreprintBiochemistry

Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

L. Qu, Z. Yi, Y. Shen, L. Lin, F. Chen, Y. Xu, Z. Wu, H. Tang, X. Zhang, F. Tian, C. Wang, X. Xiao, X. Dong, L. Guo, S. Lu, , W. Wei

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

bioRxiv · Mar 16, 2021Immunology

Metapopulation Structure of Diatom-associated Marine Bacteria

L. Qu, X. Feng, Y. Chen, L. Li, X. Wang, Z. Hu, H. Wang, H. Luo

The paper investigates the metapopulation structure of marine bacteria associated with diatoms, finding that closely related bacterial populations are host-specific and show functional differentiation.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology

Endonuclease activity of RecJ from extremely alkaliphilic Bacillus alcalophilus

M. Zheng, W. Wang, L. Ma, L. Wang, L. Qu, X. Liu, H. Liu

This study identifies a novel RecJ from Bacillus alcalophilus with endonuclease activity, distinct from previously known exonucleases, and highlights its potential as a gene editing tool.

bioRxiv · Feb 19, 2020 · PreprintMicrobiology

A common problem in the purification of calicivirus raised by molecular sieving: balance between purification and loss of viral particles

Z. Qu, H. Kang, C. Cui, K. Meng, X. Zhang, L. Qu, G. Meng

This study evaluates the impact of molecular sieving on Feline Calicivirus stability using cryo-EM and develops a scoring system to assess purification effects.

bioRxiv · Feb 4, 2020 · PreprintMicrobiology

Optical Sectioning of Live Mammal with Near-Infrared Light Sheet

F. Wang, H. Wan, J. Yue, M. Zhang, Z. Ma, Q. Sun, L. Qu, H. Ma, Y. Zhong, Y. Tian, G. Hong, W. J. Li, Y. Liang, L. Liu, H. Dai

This paper develops near-infrared light sheet microscopy to image live mammals, revealing tumor dynamics and PD-L1 receptor distribution at the single-cell level.

bioRxiv · Oct 18, 2018 · PreprintBioengineering