Within-sibship GWAS improve estimates of direct genetic effects
Laurence J Howe, Michel Guillaume Nivard, Tim Morris, Ailin Falkmo Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Penelope A. Lind, Teemu Palviainen, Matthijs D. van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klarić, , Neil M Davies
In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.
bioRxiv · Mar 5, 2021 · PreprintGenetics✦ In-depth digest