Author

T. M. Yaron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. L. Johnson· 6 shared L. C. Cantley· 5 shared B. E. Nilsson-Payant· 3 shared E. R. Kastenhuber· 3 shared R. E. Schwartz· 3 shared B. R. tenOever· 2 shared S. Chen· 2 shared T.-Y. Lin· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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6 shared papersMicrobiology

J. L. Johnson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Epinephrine inhibits PI3K alpha via the Hippo kinases.

T.-Y. Lin, S. Ramsamooj, K. Liberatore, L. Lantier, N. Vasan, K. Karukurichi, S.-K. Hwang, E. A. Kesicki, E. R. Kastenhuber, T. Wiederhold, T. M. Yaron, M. Zhu, Y. Ma, M. N. Paddock, G. Zhang, , M. D. Goncalves

The paper identifies Hippo kinases as inhibitors of PI3K alpha, showing epinephrine activates these kinases to suppress insulin signaling and glucose metabolism.

bioRxiv · Jul 19, 2022 · PreprintPhysiology

Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses

E. R. Kastenhuber, M. Mercadante, J. L. Johnson, T. M. Yaron, L. C. Cantley

The paper examines how SARS-CoV-2 variants interact with host proteases and shows that some proteases remain effective against variant spike proteins.

bioRxiv · Jun 16, 2022 · PreprintMicrobiology

NAK associated protein 1/NAP1 is required for mitosis and cytokinesis by activating TBK1

S. Paul, S. Sarraf, K. H. Nam, L. Zavar, S. R. Biswas, L. E. Fritsch, N. DeFoor, T. M. Yaron, J. L. Johnson, E. M. Huntsman, L. C. Cantley, A. Ordureau, A. M. Pickrell

This study identifies NAP1 as a critical regulator of TBK1 activation at centrosomes during mitosis and cytokinesis, revealing its role in cell division through substrate interactions and degradation.

bioRxiv · Mar 9, 2022 · PreprintCell Biology

SARS-CoV-2 hijacks p38β/MAPK11 to promote viral protein translation

C. A. Higgins, B. E. Nilsson-Payant, A. Kurland, C. Ye, T. M. Yaron, J. L. Johnson, B. Bonaventure, P. Adhikary, I. Golynker, B. R. Rosenberg, O. Danziger, M. Panis, L. C. Cantley, L. Martinez-Sobrido, B. R. tenOever, J. R. Johnson

This study identifies p38β as a critical host factor for SARS-CoV-2 replication and shows that inhibiting it reduces viral replication and cytokine production.

bioRxiv · Aug 20, 2021 · PreprintMicrobiology

The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro

T. M. Yaron, B. E. Heaton, T. M. Levy, J. L. Johnson, T. X. Jordan, B. M. Cohen, A. Kerelsky, T.-Y. Lin, K. M. Liberatore, D. K. Bulaon, E. R. Kastenhuber, M. N. Mercadante, K. Shobana-Ganesh, L. He, R. E. Schwartz, , M Kavanagh-Williamson

This study identifies Alectinib as an FDA-approved drug that inhibits SARS-CoV-2 nucleocapsid phosphorylation and viral replication in vitro by targeting host kinases.

bioRxiv · Aug 14, 2020 · PreprintMicrobiology

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

Y. Han, L. Yang, X. Duan, F. Duan, B. E. Nilsson-Payant, T. M. Yaron, P. Wang, X. Tang, T. Zhang, Z. Zhao, Y. Bram, D. Redmond, S. Houghton, D. Nguyen, D. Xu, , S. Chen

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

bioRxiv · May 5, 2020 · PreprintMicrobiology