X. Du

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

This study evaluates the therapeutic effects of IL12IL2GMCSF fusion protein in canine tumors, showing significant response rates with minimal adverse effects.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

This study shows adolescent female rats in estrous phases with high estradiol levels show delayed fear extinction compared to males and ovariectomized females.

This study shows that iso-PhABA improves grape color and anthocyanin content more than ABA by enhancing enzyme activity and receptor affinity.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This study shows that silicon enhances plant resistance against powdery mildew through distinct, multi-layered defense mechanisms involving PAD4-dependent and SA-independent pathways.

This paper introduces a new transcranial magnetic stimulator coil design that improves depth-focality tradeoff and allows adjustable focal spot size for deep brain stimulation.

The paper investigates how E7820 recruits RBM39 to the DCAF15 E3 ligase complex through structural and kinetic analysis, revealing its mechanism as a molecular glue.

This study shows that deleting PTPN2 in T cells improves anti-tumour immunity and CAR T cell effectiveness against solid tumours.

This study investigates how rFIP-glu modulates macrophage immune responses via distinct signaling pathways, showing its potential therapeutic applications.

The paper presents a live imaging platform for the Drosophila adult midgut to study cell division, differentiation, and loss in real time, revealing new cell behaviors.

The paper shows PGC-1α and Bcl-2 work together to reduce ROS and delay cell cycle progression in U251 cells after serum depletion.