X. Peng

This study uses TMT-based proteomics to analyze the antibacterial effects of YACTH against Staphylococcus aureus, identifying 490 differentially expressed proteins and their biological pathways.

The paper analyzes metagenome-derived DGRs to show their evolutionary origin, mutation bias, ecological niches, and role in microbial community dynamics.

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

This study develops a far-red probe and microfluidic platform to image live erythrocyte membranes at the single-molecule level, enabling high-throughput super-resolution and tracking.

This study shows that HDAC5 deacetylates IFIT2, promoting glioma stemness and progression by inducing IFIT2 ubiquitination and loss of anti-tumor activity.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

The paper introduces topological methods to identify mutation hot-spot sites in proteins, using the SARS-CoV-2 spike protein as an example, and finds that D614G and N501Y are notable hot-spots.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.

The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This study evaluates isopropoxy benzene guanidine's antimicrobial activity against S. aureus, showing potent activity and low resistance potential.

This study identifies circ_0005962 as an oncogene in NSCLC that promotes progression via the circ_0005962/miR-382-5p/PDK4 regulatory network.

The study shows that millet-based supplements improve gut microbiota diversity in undernourished pigs more effectively than corn-based supplements.

This study uses long-read sequencing to profile full-length Ig and TCR repertoires in rhesus macaques, revealing significant diversity missed by traditional methods.

This study compares protein metabolism and regeneration in diaphragm and gastrocnemius muscles of hibernating and summer-active Daurian ground squirrels, finding distinct regulatory patterns contributing to hypertrophy and atrophy.

The paper identifies peptides that enhance drug delivery through mucus and epithelial barriers in CF patients using phage libraries and sequencing.

This paper shows that papillomavirus can be transmitted through blood and cause infections in animal models, suggesting blood transfusion as a potential route for HPV infection and cancer in humans.

The paper identifies a peptide coating that enhances nanoparticle diffusion through the tumor microenvironment by screening phage libraries and testing transport in vitro and ex vivo.

The paper describes a large animal exposure chamber for controlled air pollutant studies, demonstrating uniform dispersion and inhalation-based dosing of particulate matter.

This study shows that vitamin A supplementation after neonatal Streptococcus pneumoniae pneumonia reduces allergic asthma in mice by altering CD4+ T cell subsets.

This study presents the cryo-EM structure of the mouse TRPC4 ion channel, revealing unique features that contribute to its ion selectivity and evolutionary diversity within the TRP family.

This study identifies a novel xanthan gum degradation pathway in Thermogutta terrifontis using genomic and transcriptomic analysis, revealing unique enzymes and metabolic capabilities.