X. Ren

This study shows that mitochondrial UPR suppresses wounding-induced innate immunity in C. elegans epidermis by inhibiting ATFS-1 and modulating downstream signaling pathways.

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

This study engineers vascularized adipose tissue grafts using a decellularized lung matrix, showing successful integration of adipose cells and endothelial cells in perfusion cultures.

This study shows that beta-catenin limits osteogenesis on stiff nanoparticulate mineralized collagen glycosaminoglycan scaffolds by modulating Wnt and mechanotransduction pathways.

This study determines the crystal structure of WIPI2 interacting with ATG16L1, revealing the molecular mechanism of ATG16L1 recruitment to the phagophore and its role in autophagy initiation.

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

This study identifies exosomal miR-224's role in maintaining hemolymph microbiota homeostasis during bacterial infection in mud crabs by modulating immune signaling pathways.

This study investigates N-glycosylation sites and glycan-binding ability of SARS-CoV-2 S-protein through phylogenetic analysis, structural comparison, docking analysis, and molecular dynamics simulation.

This study evaluates the cardiac effects of azithromycin and hydroxychloroquine plus azithromycin in guinea pigs, finding QT interval prolongation and cardiac dysfunction with both treatments.

The paper determines the crystal structure of SARS-CoV-2 ORF8, revealing unique dimerization interfaces that may enable immune evasion.

This study shows that blocking integrin αvβ8 on T cells enhances anti-tumor immunity in multiple syngeneic models and is effective even when tumor cells do not express the integrin.

The paper identifies a distinct SARS-CoV-2 clade linked to travellers returning from Iran to Australia and New Zealand through whole genome sequencing and phylogenetic analysis.

This study shows that increasing stiffness of MC-GAG scaffolds enhances osteogenesis through YAP/TAZ and Wnt signaling, while BMPR signaling is independent of mechanical cues.

The paper investigates exosome-mediated apoptosis during WSSV infection in mud crabs, identifying miR-137 and miR-7847 as negative regulators of apoptosis by targeting AIF.

The paper develops a computational method to detect isoform usage in T cells from non-small cell lung cancer and identifies gene-specific isotype preferences linked to T cell function.

This study shows that banana supports better larval development and bacterial growth in Bactrocera dorsalis compared to apple, suggesting a link between host fruit quality and gut microbiota.

The paper determines the structure of SIV Nef interacting with simian tetherin and AP-2, revealing how Nef bypasses tetherin's antiviral function by refolding AP-2 and creating a binding site for the DIWK motif.

This study shows that ischemic stroke alters pulmonary immunity independently of pneumonia by reducing immune cell percentages and chemokine levels in the lungs.

This study shows that Cbx2 forms condensates via phase separation, which may organize PcG-bound chromatin.

The paper develops a platform to infer and validate signaling interactions at cellular resolution during C. elegans embryogenesis, identifying Notch interactions and their role in breaking fate symmetry.

ESCRT-III and Vps4 were reconstituted to generate ATP-dependent forces for membrane scission, confirming their role in membrane cutting.