X. Wu

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

This study determines the structural mechanism of HECT-type E3 ligase Ufd4 in catalyzing K29/K48-branched polyubiquitination by capturing structural snapshots of Ub transfer cascades.

The paper shows that genetic excision of a cardiac troponin I extension in mammals allows for high heart rates by mimicking phosphorylation without adrenergic stimulation.

This study creates a pH-insensitive NCX1 mouse and finds it has reduced growth, accelerated cardiac repolarization, and is resistant to ischemia/reperfusion injury.

This study identifies a murine gut protozoan that alleviates Clostridium difficile infection by modulating arginine metabolism and host immune responses.

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

The paper investigates metal-driven anaerobic methane oxidation in cold seep sediments, finding that Fe-AOM and Mn-AOM contribute ~3% to methane removal.

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

This study identifies syndecan-1 and thrombomodulin as early biomarkers of endotheliopathy in trauma and hemorrhagic shock using rat models.

This study identifies GrgA as essential for Chlamydia's secondary differentiation from reticulate bodies to infectious elementary bodies using a novel gene knockdown strategy.

This study shows ATF6 enhances TH2 and TH17 cell responses and contributes to mixed granulocytic airway inflammation, suggesting ATF6 inhibition as a potential therapy for steroid-resistant asthma.

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

This study shows that galactosylated glycoproteins from bovine milk inhibit both SARS-CoV-2 and influenza virus by blocking their interaction with ACE2.

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

This study characterizes the tumor microenvironment in colorectal cancer using multi-omics and spatial analysis, identifying four subtypes with distinct features and therapeutic responses.

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

The paper identifies a proliferative cell population in ER+ metastatic breast cancer using spatial and single-cell transcriptomics, showing its role in estrogen-dependent growth and clinical outcomes.

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

This study shows FTO stabilizes LINK-A, promoting ESCC progression through MCM3-mediated cell cycle progression and HIF-1α activation.

This paper introduces multifunctional ferromagnetic fiber robots capable of navigation, sensing, and treatment in minimally invasive surgery, demonstrating their use in electrophysiology sensing and localized treatment.

HYENA identifies oncogenes, including non-coding genes, activated by enhancer hijacking in cancer using whole-genome and transcriptome sequencing data.

The paper introduces a metadata catalog to enhance findability of sickle cell disease studies using FAIR principles through curated metadata and search tools.

The paper identifies eEF2 as a prognostic biomarker for dense connective tissue repair outcomes and shows it regulates cellular processes to improve healing.

This study shows adenoviral infection causes arrhythmogenic changes in the heart before significant immune response, through gap junction and ion channel dysfunction.

This paper identifies CX3CR1+ CD8+ T cells with low mitochondrial membrane potential as functionally resilient, showing high cytotoxicity and reduced ROS through ME1 upregulation, which enhances their anti-tumor activity.

This study shows that combining mesenchymal stromal cells and alpha-1 antitrypsin significantly improves inflammation modulation and resolution in vitro and in a mouse model.

This study shows that fibronectin improves calcium signaling and myofilament activation in diabetic cardiomyocytes by enhancing integrin-ECM interactions and mechanical properties.

The paper identifies beta-oscillations in cortico-striatal regions as markers of learned reward value across multiple behavioral tasks in rats.