X. Wu

The paper develops a single-well droplet digital PCR method to simultaneously detect pathogen and host allele types, showing DRB3*009:02 alleles suppress BLV proviral load.

This paper develops a visual perception system using pose estimation to analyze fish swimming and provides code and dataset for the method.

This study analyzes codon usage changes in SARS-CoV-2 over time, finds that deoptimization may reduce protein expression, and designs codon-optimized mRNA vaccine candidates for Omicron variants.

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This study identifies HCP5 as a key antiapoptotic factor in ESCC by preventing UTP3 degradation and activating c-Myc to suppress apoptosis.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

This paper identifies a new class of TEAD-YAP inhibitors with a novel binding mode that suppresses transcriptional activity and shows anti-proliferative effects in cancer cells.

This paper develops an imaging flow cytometry method to quantify temperature-induced platelet shape change, showing a consistent transition from fusiform to circular shapes in mouse and human platelets.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

This study evaluates the use of nanopore sequencing for SNP and cgMLST subtyping of Salmonella Enteritidis, showing high concordance with Illumina data despite sequencing errors.

This paper develops a bacteriophage-based mucosal vaccine that induces strong immune responses and protects against SARS-CoV-2 and its variants without requiring needles or adjuvants.

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

This study shows no evidence of skin cancer or abnormalities in mice after 66 weeks of far-UVC exposure, supporting its long-term safety.

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

The paper investigates N2O emissions in two agricultural soils by analyzing denitrifying bacterial communities and their metabolic phenotypes, finding that differences in bacterial composition and gene function drive variations in N2O accumulation.

The paper investigates how alternative 3' UTRs regulate gene expression in response to high salt stress in Spartina alterniflora, showing that 3' UTR lengthening enhances RNA stability and protein synthesis of stress-related genes.

This study shows that modifying CAR activation motifs improves anti-tumor efficacy in solid tumors despite reduced in vitro cytotoxicity.

This study identifies D-AS2 as a noncoding RNA that promotes chemoresistance in SCC by activating YAP signaling through the PLD/PA axis, and shows that targeting D-AS2 sensitizes SCC to cisplatin.

The paper reports the NMR solution structure of the SetA-CTD domain from Legionella pneumophila, revealing its PI(3)P binding mechanism and structural features important for membrane association.

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

This study shows Myo10 maintains mitotic spindle bipolarity by preserving PCM integrity and promoting supernumerary centrosome clustering in cancer cells.

The paper shows lung-derived C3 reduces pneumonia-induced lung injury through the Factor B pathway, independent of circulating C3 levels.

This study combines emodin with low-frequency low-intensity ultrasound to treat osteomyelitis by enhancing antibacterial and anti-biofilm effects through sonoantimicrobial chemotherapy.

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

This study measures S4 movement in KCNQ2 channels to uncover how epilepsy-causing mutations affect voltage-dependent gating.

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

The paper identifies sulfane sulfur-mediated post-translational modification of AdpA in Streptomyces coelicolor, enhancing actinorhodin production and morphological differentiation.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.