X. Zhou

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

This study shows mTORC2 promotes Tfh differentiation and disrupts Treg homeostasis, contributing to systemic autoimmunity, and suggests mTORC2 as a potential therapeutic target.

This study shows that dense collagen matrices impair CTL migration and cytotoxicity, with microtubule networks playing a key role in restoring migration and function.

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

This paper identifies host-derived reactive nitrogen species as key drivers of the Cryptococcus neoformans yeast-to-titan switch by increasing endogenous superoxide, which promotes genotoxic stress and polyploidy, while requiring SOD activity for titan cell viability.

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.

This study compares gait stability and acceleration characteristics between healthy young and older females using inertial sensors, finding older females exhibit less stability and more variability in trunk and foot movements.

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

This study shows that CRTC-CREB activation drives LKB1-null lung cancer growth and identifies it as a therapeutic target.

The paper uses ATAC-seq to reveal megabase-scale domains of bacterial nucleoids in Caulobacter crescentus, showing they are shaped by DNA gyrase and GapR.

This study investigates T cell stiffness changes during immunological synapse formation using atomic force microscopy, revealing differential stiffening in lamellipodia and cell body.

This study shows that matrix stiffness and blood pressure together drive vascular smooth muscle cell phenotypic switching and cofilin-dependent podosome formation in atherosclerosis.

This study examines how parasitaemia levels during Plasmodium yoelii infection in mice affect intestinal microbiota composition and correlate with immune cell development.

The paper identifies a bacterial endosymbiont in Rhizopus microsporus that enhances fungal virulence by suppressing amoeba predation and macrophage clearance.

This study uses transcriptomic data to resolve the phylogenetic relationships within Antliophora, finding fleas are sister to either a monophyletic Mecoptera or arose within mecopteran families, potentially making Mecoptera paraphyletic.

The paper analyzes the genomes and phenotypes of four Aspergillus fumigatus isolates from COVID-19 patients, finding minor genomic differences and variable virulence traits.

This study investigates how light intensity affects the coloration and structure of chimeric leaves in Ananas comosus var. bracteatus, finding that 50% shade optimizes growth and ornamental value.

This study examines genetic and phenotypic variations in Pseudomonas aeruginosa PAO1 sublines due to microevolution, showing how mutations in lasR and mexT affect quorum sensing and virulence.

The paper shows how the MEN signal is transmitted from the cytoplasm to the nucleolus through kinase-mediated phosphorylation in budding yeast.

This study shows SpRY expands CRISPR editing in rice by recognizing diverse PAMs, enabling efficient genome modification across various loci.

The paper introduces a framework to quantify microbial community assembly mechanisms in grassland soils under warming, finding homogeneous selection and drift dominate, with warming altering their relative contributions.

This study shows that H2-GMZ reduces cyst formation in ADPKD by inhibiting Cl- secretion, cell proliferation, and motility in both in vitro and in vivo models.

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

The study validates a GWAS finding showing a mutant Azi2 allele increases methamphetamine sensitivity, but the mechanism does not involve Slc6a3 regulation.

This study shows that changes in plasma cfDNA levels during chemotherapy predict clinical response in NSCLC patients, with specific insights for lung adenocarcinoma.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study uses transcriptomics to resolve the phylogenetic relationships of Odonata, finding monophyletic damselfly and dragonfly families and estimating their origins in the late Triassic.

This paper improves HDR efficiency for gene knock-in in poplar by combining XRCC4 silencing with CtIP and MRE11 overexpression, achieving higher knock-in rates and fewer InDels.

The paper shows red-light promotes mutualism between begomovirus and whitefly by stabilizing βC1, which inhibits plant defenses through interference with PIFs and MYC2 transcriptional activity.

The paper investigates how the HD-ZIP IV transcription factor mutant ocl4 affects 21-nt phasiRNA accumulation in maize anthers under different environmental conditions, finding that these phasiRNAs buffer development under stress.