X. Zhou

This study investigates how binding affinity and conformational preferences affect the kinetic stability of short oligonucleotides on carbon nanotubes using simulations and experiments.

The paper creates a single nucleus multi-omics atlas of the murine pituitary, revealing cell type-specific regulatory mechanisms and identifying a cis-regulatory region linked to fertility.

This study examines layer-specific retinal vascular reactivity in diabetic patients and finds impaired responses to oxygen and carbon dioxide in deep retinal layers.

This study identifies ARTS as a p53-responsive gene that promotes mitochondrial apoptosis by interacting with p53 and enhancing its pro-apoptotic effects.

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

This study constructs a genome-scale phylogeny of Ascomycota fungi, revealing contrasting modes of genome evolution across subphyla.

This study investigates how neoantigen heterogeneity affects bystander immune inhibition in pancreatic cancer, finding that high neoantigen frequency is needed for effective antitumor response, which can be improved with immune therapy.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

The paper shows that monounsaturated fatty acids (MUFA) are essential for B cell function and humoral immunity, with SCD-mediated MUFA production supporting early B cell development and germinal center formation.

The paper uses a HOXA9-mCherry reporter and CRISPR/Cas9 screens to identify USF1/USF2 as regulators of HOXA9 in MLLr leukemia, showing their role in leukemia cell proliferation.

The paper identifies poly(ADP-ribose) as a regulator of ASK3 phase separation, enabling osmotic stress recognition and cell volume regulation.

This paper develops a magnetic flow cytometer using a GMR SV biosensor array and matched filtering to enable reliable point-of-care diagnostics for noncommunicable diseases.

The paper identifies MTHFD1 as a target for broad antiviral therapy by screening bat cells with RNAi and CRISPR libraries against mumps and influenza viruses.

This study shows how low complexity head domains transiently form structured β-strand-enriched polymers that influence intermediate filament assembly and cell morphology.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

Knockout of 4CL1 in Populus reveals a 4CL5-dependent compensatory pathway for lignification with links to thiol redox balance and sulfur assimilation.

This study shows that Tomato spotted wilt virus extends the developmental time and increases progeny production in western flower thrips, with a male-biased sex ratio, likely enhancing virus transmission.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study shows that recombinant human MG53 protein protects cardiomyocytes from ischemia-reperfusion-induced oxidative stress by preserving mitochondrial integrity.

This study identifies a policing behavior in termites that regulates reproductive division of labor by older reproductives attacking younger ones, with worker assistance in cannibalizing the injured.

This study develops a giant magnetoresistive biosensor to detect protease activity by measuring magnetic nanoparticle release, showing sensitivity to papain in urine.

This study identifies differences in the oral microbiome between NPC patients and controls, highlighting a pair of co-excluding Granulicatella adiacens variants associated with cancer risk.

The paper investigates the relationship between titan cells, small cells, and titanides in Cryptococcus neoformans, showing their shared features and impact on aneuploidy and drug resistance.

This study shows that redox regulation controls TDP43 low complexity domain aggregation into cross-β polymers, with implications for neurodegenerative diseases.

The paper identifies P5CS as a CTPS-interacting protein in Drosophila and shows they form cytoophidia, linking two enzymes in pyrimidine and proline biosynthesis.

This study uses single-cell RNA sequencing to analyze how perinatal lead exposure affects hippocampal cell types in mice, finding increased oligodendrocytes and altered gene expression in specific cell clusters.

This study identifies Notopterol as a JAK2/3 inhibitor that reduces inflammation and arthritis by blocking macrophage cytokine production in animal models.

This study compares bacterial diversity in raw and pasteurized goat milk using high-throughput sequencing, identifying new bacterial species and viable but nonculturable bacteria.

The paper develops a droplet-digital Cas13a assay for single-molecule microRNA quantification, demonstrating its precision, specificity, and broad applicability.