X. Zhou

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

This paper introduces a fast MRSI technique for musculoskeletal fat quantification, producing separate lipid component maps with improved sensitivity compared to standard Dixon methods.

This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.

The paper introduces a phylogenetic tree-based pipeline to identify statistically significant mutations in influenza virus evolution, applied to H3N2 HA sequences over 50 years.

CASLFA enables rapid, specific detection of pathogens and GMOs with high sensitivity and no technical expertise.

The paper develops a method to generate scaled musculoskeletal neck models using anthropometric data and optimization, showing accuracy in geometry and strength.

The paper investigates how transcription factor networks modulate growth and defense in Arabidopsis, finding that their effects are conditional and not simply correlated.

This paper develops a CRISPR-based colorimetric gene detection platform using AuNPs that enables naked-eye detection of DNA and RNA targets with high sensitivity and universality.

This study characterizes the colonization dynamics of Rhodopseudomonas palustris GJ-22 on tobacco phyllosphere and shows it induces plant resistance to Tobacco mosaic virus.

This study identifies two lineages in Hanseniaspora yeasts, showing the FEL lineage lost more cell cycle and DNA repair genes than the SEL lineage, likely due to accelerated evolution and increased mutational load.

This study shows that protein self-assembly alone can form and maintain bacterial surface layers, guided by surface topology without enzymatic assistance.

This study investigates how rFIP-glu modulates macrophage immune responses via distinct signaling pathways, showing its potential therapeutic applications.

This study characterizes the viral community of the South Scotia Ridge using metagenomic analysis, revealing novel viral sequences and high diversity.

This study identifies adaptive gene family expansions in polyphagan beetles associated with their shift to plant-feeding, supporting the role of plant chemical defenses in beetle diversification.

This paper develops a simian-adenovirus-vectored rabies vaccine that can be thermostabilized and administered as a single dose, showing potent immunogenicity and potential for low-cost pre-exposure prophylaxis.

This study demonstrates that genome-skimming accurately quantifies mixed pollen samples, showing high repeatability and correlation between sequence reads and pollen proportions.

The paper reports the horizontal transfer of a bacterial operon into yeast, showing its adaptation to eukaryotic gene expression and iron acquisition in an insect gut environment.

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

This study evaluates how cytological preparation affects nanoscale chromatin changes using PWS microscopy in cancer cell models, showing that modifications can preserve clinically relevant nanoscopic differences.

This study shows that TXNIP mediates ER stress-induced NLRP3 inflammasome activation, leading to IL-1β production in preeclampsia.

This study shows PCDH7 promotes lung cancer growth in mice by accelerating KrasG12D-driven tumorigenesis and enhancing MAPK pathway activation, while its loss reduces tumor development and extends survival.

The paper presents the structure of human TRPC6 ion channel in complex with inhibitor BTDM, revealing its architecture and inhibition mechanism.

ADS-J1 disassembles semen-derived amyloid fibrils and prevents their re-aggregation, showing potential as a microbicide and treatment for amyloid diseases.

This study evaluates four maximum likelihood phylogenetic programs on empirical data sets, finding that exhaustive methods outperform faster ones for single-gene trees and IQ-TREE excels in concatenation-based species tree inference.

The paper introduces quartet-based measures to quantify phylogenetic incongruence, showing they are more accurate and robust than bipartition-based methods, especially with partial trees and missing data.

This study shows that neotenic reproductives in termites regulate worker-reproductive transition differently in males and females, inhibiting same-sex workers and stimulating opposite-sex workers.

The paper shows that reduced dependence on a co-activator expanded the target genes of a transcription factor during evolution in C. glabrata.