Author

Xiaoan Ruan

The Jackson Laboratory for Genomic Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Yijun RuaniD· 3 shared Byoungkoo LeeiD· 2 shared Chia‐Lin WeiiD· 2 shared Jacqueline Jufen ZhuiD· 2 shared Meizhen ZhengiD· 2 shared Ping WangiD· 2 shared Simon Zhongyuan TianiD· 2 shared Akashi Taguchi· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersGenomics

Yijun RuanORCID

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Author profile →

4 papers

Recent·Most cited

Chromatin Topology Reorganization and Transcription Repression by PML/RARα in Acute Promyeloid Leukemia

Ping Wang, Zhonghui Tang, Byoungkoo Lee, Jacqueline Jufen Zhu, Liuyang Cai, Przemysław Szałaj, Simon Zhongyuan Tian, Meizhen Zheng, Dariusz Plewczyński, Xiaoan Ruan, Edison T. Liu, Chia‐Lin Wei, Yijun Ruan

This study investigates how PML/RARα alters chromatin topology and transcription in APL cells, revealing its role in repressing myeloid differentiation genes.

Genome biology · May 11, 2020Peer-reviewedGenomics

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

Yoshiki Higashijima, Yusuke Matsui, Teppei Shimamura, Ryo Nakaki, Nao Nagai, Shuichi Tsutsumi, Yohei Abe, Verena M. Link, Mizuko Osaka, Masayuki Yoshida, Ryo Watanabe, Toshihiro Tanaka, Akashi Taguchi, Mai Miura, Xiaoan Ruan, , Yasuharu Kanki

The paper shows that KDM7A and UTX demethylate repressive histone marks to enable NF-κB-dependent inflammatory gene activation in endothelial cells.

The EMBO Journal · Mar 3, 2020Peer-reviewedMolecular Biology

The genome of C57BL/6J \"Eve\", the mother of the laboratory mouse genome reference strain

Vishal Sarsani, Narayanan Raghupathy, Ian T. Fiddes, Joel C. Armstrong, Françoise Thibaud‐Nissen, Oraya J. Zinder, Mohan T. Bolisetty, Kerstin Howe, Doug Hinerfeld, Xiaoan Ruan, Lucy B. Rowe, Mary E. Barter, Guruprasad Ananda, Benedict Paten, George M. Weinstock, , Laura G. Reinholdt

The paper generates a new de novo genome assembly for C57BL/6J Eve, addressing genetic drift in the reference strain and improving genomic accuracy.

G3 Genes Genomes Genetics · Apr 18, 2019Peer-reviewedGenomics

Multiplex Chromatin Interaction Analysis with Single-Molecule Precision

Meizhen Zheng, Simon Zhongyuan Tian, Rahul Maurya, Byoungkoo Lee, Minji Kim, Daniel Capurso, Emaly Piecuch, Liang Gong, Jacqueline Jufen Zhu, Chee‐Hong Wong, Chew Yee Ngan, Ping Wang, Xiaoan Ruan, Chia‐Lin Wei, Yijun Ruan

This paper introduces a method to analyze multiplex chromatin interactions with single-molecule precision and shows they contribute to topologically associated domains and gene regulation.

bioRxiv · Jan 25, 2018 · PreprintGenomics