Y. Chen

This study reports lipidomic analysis of six RCA roseobacter isolates, revealing unique phospholipid synthesis and adaptation to phosphorus limitation.

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

The paper identifies two amino acids in the RB gene that modify its interaction with the effector IPI-O4, affecting resistance to Phytophthora infestans in potato.

This study develops a platform combining deep learning and high-content imaging to identify disease-specific phenotypes in Parkinson's fibroblasts, achieving high accuracy in distinguishing disease subtypes.

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

An intron-1 rearrangement in the MADS-box transcription factor VRT-A2 leads to its misexpression and defines the long-glume phenotype of Polish wheat (T. polonicum).

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

The paper identifies a novel ATP-dependent DMSP lysis pathway in bacteria, revealing a new route in the marine sulfur cycle through the enzyme AcoD.

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.

This study shows that BCP and Pre-C mutations in HBV increase viral replication but reduce immune tolerance, with Pre-C mutations causing more severe immune responses and shorter viral persistence in mice.

This study shows that lack of Bifidobacteria in early life is linked to immune dysregulation, and B. infantis EVC001 reduces intestinal Th2 and Th17 responses while promoting Th1 polarization.

This study investigates how metabolic dysfunction, specifically through hyperacylation of histones and cohesin, affects chromatin structure across multiple scales, revealing metabolic regulation of chromatin organization.

The paper reports cryoEM structures of DNA-PKcs in inactive and activated forms, revealing structural changes in HEAT repeats that drive kinase activation.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study identifies KIM1 as a potential receptor for SARS-CoV-2 in the kidney, showing it binds RBD with similar affinity to ACE2 and facilitates viral entry.

This study identifies EGFR downregulation as a mechanism by which HPV infection improves prognosis in cervical and head and neck cancers, suggesting EGFR inhibitors could be potential anti-HPV therapies.

This study identifies exosomal lncRNA PICALM-AU1 from cholangiocytes as a key regulator of endothelial-mesenchymal transition in hepatopulmonary syndrome, with potential as a biomarker and therapeutic target.

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

The paper validates two maize PHT QTVs using UAS to show their dynamic effects across genetic backgrounds and growth stages, revealing overlooked phenotypic variability.

This study shows SARS-CoV-2 and GX_P2V can infect human endoderm, ectoderm, and lung progenitor cells derived from hESCs, with some infections blocked by whey protein and Remdesivir.

This study manipulates phloem transport in white pines to examine its effects on wood formation and carbon dynamics, finding increased tracheid production but stable nonstructural carbon concentrations.

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

This study designs engineered proteases that specifically degrade active RAS by cleaving a conserved sequence in switch 2, showing efficacy in vitro and in human cell culture.

The paper identifies a diamide inhibitor of Streptococcus pneumoniae growth and shows that genetic and chemical inactivation of autolysins yield different phenotypic outcomes.

This study identifies the transcriptomic response of staphylococci to D-sphingosine and reveals mechanisms of resistance, including mutations in FarE-FarR efflux proteins.

The paper develops closed-form approximations for Ca2+ nanodomains with two-binding-site buffers, showing improved accuracy over existing models.

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

This study compares the cooperativity of ACE2 binding to SARS-CoV-1 and SARS-CoV-2 Spike proteins, finding that SARS-CoV-2 exhibits positive cooperativity.