Y. Chen

This study identifies over three times more proteins from secreted and cell-surface proteomes of C. diphtheriae than previous studies, revealing virulence-related proteins and iron-regulated pathways.

The paper develops efficient approximations for stationary Ca2+ nanodomains near a single channel, improving accuracy across parameter space using novel interpolation and variational methods.

This study uses molecular dynamics and experimental methods to show that phosphorylation of CheY increases its affinity for FliMN by altering conformational dynamics and sidechain burial.

This study identifies differentially expressed proteins and phosphosites in porcine granulosa cells during follicular atresia, revealing potential biomarkers and pathways involved in the process.

This paper presents a method for site-specific covalent labeling of large RNAs using expanded genetic alphabet transcription and gold nanoparticles, validated by X-ray scattering interferometry.

This paper identifies distinct cellular strategies in Arabidopsis accessions that determine their sensitivity to mild drought, highlighting stomatal closure and cell expansion as key factors.

The paper analyzes SARS-CoV-2 quasispecies structure using SMRT sequencing, revealing a One-King model with dominant and minor haplotypes and their evolutionary dynamics.

This study shows that whey protein from human and other animal milk inhibits SARS-CoV-2 and GX_P2V in vitro by blocking viral attachment, entry, and replication.

This study identifies tafenoquine as an inhibitor of SARS-CoV-2 main protease, showing it reduces protease activity and inhibits viral infection in vitro.

This study evaluates cefepime-induced neurotoxicity by analyzing trough concentrations, clinical factors, and EEG findings in hospitalized patients.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

This paper develops membrane nanoparticles from ACE2-rich cells that effectively block SARS-CoV-2 infection by trapping the viral S1 protein and inhibiting its interaction with host cells.

The paper identifies a potent neutralizing nanobody against SARS-CoV-2 with high activity and stability for inhaled delivery.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

This study identifies site-specific O-glycosylation patterns in SARS-CoV-2 spike proteins, revealing host-dependent variations and their potential implications for viral function and therapeutic development.

This study shows that clathrin light chain diversity affects membrane deformation and synaptic vesicle formation, with isoform mixing being necessary for optimal neuronal function.

The paper introduces COCO-Search18, a dataset of goal-directed eye-movement behavior, and benchmarks models for predicting search fixations using deep learning methods.

The paper introduces a machine learning approach to classify single-cell data by learning from manually curated phenotypes, improving reproducibility and efficiency compared to manual methods.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

The paper identifies 9240 lncRNAs in diploid cotton using multi-omics data and reveals their transcriptional regulation and co-expression with protein-coding genes and GWAS SNPs.

This study shows hESCs-derived lung organoids can reconstruct human airway epithelium in vivo, with CD47high cells enhancing ciliated cell generation and epithelial thickness.

The paper compares gene expression of Colletotrichum fructicola from two geographic regions after inoculating Camellia oleifera, finding differences in metabolic pathways linked to pathogenicity.

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

This paper introduces a method to detect O-GlcNAc modifications using tandem glycan labeling and fluorescent detection, showing HIF1α as an O-GlcNAc target.

This study develops an in vitro 3D fracture gap model that mimics bone-immune cell interactions to study fracture healing mechanisms and therapeutic responses.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

The paper uses single-cell sequencing to analyze hypertrophic scars, identifying serine proteases as key regulators of myofibroblast differentiation and suggesting their inhibition for treating skin fibrosis.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study identifies inhibitors of SARS-CoV-2 main protease that show potent antiviral activity in cell culture.

This study shows that robust biofilm formation in environmental Bacillus subtilis strains reduces competent cell rates through cross-pathway regulation between biofilm and competence systems.