Y. Lin

The paper uses machine learning to analyze PTM data from lung cancer cell lines, identifying functional modules and networks that reveal crosstalk between signaling pathways and metabolic processes in response to TKIs.

This study shows that local activation of the Ras-Akt network in human neutrophils directly controls cell polarity and migration by regulating protrusions and motility.

This study identifies PbE3-2, a protist effector that degrades RD21A to suppress plant immunity, contributing to clubroot disease.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

The paper tests Darwin's hypotheses on alien plant invasion success by analyzing phylogenetic relationships across invasion stages and environmental contexts.

This study identifies high molecular weight polysaccharides in Ca. Accumulibacter EPS as rich in NulOs and suggests their potential for sepsis treatment.

This study investigates the interactions between cisplatin and E-cadherin using fluorescence spectroscopy and AFM, revealing strong binding and structural changes.

This study evaluates CRISPR/Cas9, CRISPR/LbCpf1, and base editors for targeted genome editing in grape, showing variable efficiencies and PAM specificity.

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

The paper measures EPS turnover in a PAO-enriched microbial community and finds similar turnover rates for EPS proteins and intracellular proteins, with no preferential consumption by other microbes.

This study investigates how cold-chain conditions and disinfection methods affect SARS-CoV-2 stability, finding that low temperature and seawater increase viral survival while LED light and airflow reduce it.

This study characterizes Lactococcus garvieae isolates from bovine mastitis in China, identifying genetic diversity, antimicrobial resistance, virulence factors, and potential host adaptation.

This study identifies the origin and function of circulating endothelial colony forming cells (C-ECFCs) in mice and humans, showing they arise from tissue-resident ECFCs and have vasculogenic potential.

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

This study identifies Tejas as a core component of nuage assembly and piRNA precursor processing in Drosophila, showing its role in organizing RNA helicases and regulating nuage dynamics.

The paper describes the Tara Pacific expedition's sampling methodology and provides access to datasets from coral reef and surface ocean ecosystems.

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

This study identifies three molecular subtypes of synovial sarcoma through multi-omics analysis, linking BAF complex alterations to tumor evolution and clinical outcomes.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

This paper presents an integrated platform for high-throughput single-molecule localization microscopy (SMLM) that enables imaging of 10,000 cells per day.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This paper develops a bifunctional reaction system to simultaneously resolve lipid positional and geometric isomers using mass spectrometry, revealing structural patterns in bacteria and tracking changes in mouse brain ischemia.

The paper presents a high-resolution cryo-EM structure of cyanobacterial photosystem I complexed with Cytochrome c6 and Ferredoxin, revealing binding interactions and a proposed electron transfer mechanism.

This study shows miR-138 suppresses HSV-2 lytic infection by targeting viral and host genes, with distinct mechanisms compared to HSV-1.

This study identifies that the co-deletion of CIC and ERF leads to ETV1 activation, driving prostate cancer progression without fusion events.

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

This paper introduces an active-feedback 3D single-particle tracking method to observe early virus-cell interactions with high temporal and spatial resolution.

This study identifies genomic and transcriptomic alterations in non-cirrhotic hepatocellular carcinoma, revealing recurrent mutations and structural variants that may contribute to tumorigenesis.

The paper uses mass spectrometry to determine the absolute stoichiometry of native and recombinant carboxysomes, revealing structural variability and assembly principles.