S. Arai

Harnessing Dye-induced Photothermal Confinement in Lipid Membranes: A Path to NIR-modulated Artificial Synaptic Vesicles

The paper demonstrates NIR laser-induced release of acetylcholine from VPc-embedded liposomes, causing Ca2+ flux in biospecimens.

Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

qMaLioffG: A single green fluorescent protein FLIM indicator enabling quantitative imaging of endogenous ATP

The paper introduces qMaLioffG, a green fluorescent protein FLIM indicator that quantitatively measures endogenous ATP levels by detecting fluorescence lifetime changes in physiological ATP concentrations.

Photothermal Dye-based Subcellular-sized Heat Spot Enabling the Modulation of Local Cellular Activities

The paper introduces nanoHT, a photothermal nanoparticle that creates subcellular heat spots to modulate cellular activities, inducing cell death and muscle contraction in specific areas.

Ubiquitin Ligase MARCH5 Regulates Apoptosis through Mediation of Stress-Induced and NOXA-Dependent MCL1 Degradation

This study identifies MARCH5 as a mediator of NOXA-dependent MCL1 degradation in prostate cancer, enhancing apoptosis when combined with BH3 mimetics.

Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors

This study shows that disease-associated KIF1A mutations hyperactivate motor activity, leading to increased anterograde axonal transport of synaptic vesicle precursors and contributing to motor neuron disease.