Author

Y.-X. Fu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2

Frequent Co-Authors

J. Wang· 3 shared J. Gao· 2 shared J. Sun· 2 shared S. Li· 2 shared X. Wang· 2 shared Z. Sun· 2 shared Z. Zhang· 2 shared A. Dent· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

J. Wang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity

J. Wang, S. Li, M. Wang, X. Wang, S. Chen, Z. Sun, X. Ren, G. Huang, B. D. Sumer, N. Yan, Y.-x. Fu, J. Gao

A 'shock-and-lock' nanoparticle agonist activates STING in type 1 conventional dendritic cells to enhance antitumor immunity with associated biomarkers.

bioRxiv · Jan 2, 2024Immunology

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

X. Wang, T. Zhang, B. Zheng, Y. Lu, Y. Liang, G. Xu, L. Zhao, Y. Tao, Q. Song, H. You, H. Hu, X. Li, K. Sun, T. Li, Z. Zhang, , H. Zheng

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

bioRxiv · Aug 15, 2023 · PreprintCell Biology

Mechanistic origin of different binding affinities of SARS-CoV and SARS-CoV-2 spike RBDs to human ACE2

Z.-B. Zhang, Y.-L. Xia, J.-X. Shen, W.-W. Du, Y.-X. Fu, S.-Q. Liu

This study identifies the molecular mechanisms behind the higher ACE2 binding affinity of SARS-CoV-2 RBD compared to SARS-CoV RBD using computational methods.

bioRxiv · Feb 5, 2022Biophysics

Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity

Q. Feng, Z. Liu, X. Yu, T. Huang, J. Chen, J. Wang, J. Wilhelm, S. Li, J. Song, W. Li, Z. Sun, B. Sumer, B. Li, Y.-X. Fu, J. Gao

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

bioRxiv · Oct 18, 2021Immunology

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

S. Sun, Y. Cai, T.-Z. Song, Y. Pu, L. Cheng, H. Xu, C. Meng, Y. Lin, J. Sun, S. Zhang, Y. Gao, J.-B. Han, X.-L. Feng, D.-D. Yu, Y. Zhu, , H. Peng

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

bioRxiv · May 12, 2021Immunology

Tissue-resident CD4+ T helper cells assist protective respiratory mucosal B and CD8+ T cell memory responses

Y. M. Son, I. S. Cheon, Y. Wu, C. Li, Z. Wang, Y. Chen, Y. Takahashi, A. Dent, M. Kaplan, Y.-X. Fu, J. Taylor, W. Cui, J. Sun

This study identifies tissue-resident CD4+ T helper (TRH) cells that support local B and CD8+ T cell memory responses in the lung after influenza infection.

Science Immunology · Jan 8, 2021Peer-reviewedImmunology

Trevolver: simulating non-reversible DNA sequence evolution in trinucleotide context on a bifurcating tree

C. W. Nelson, Y.-X. Fu, W.-H. Li

Trevolver simulates non-reversible DNA sequence evolution with trinucleotide context dependence on bifurcating trees, enabling testing of neutral evolutionary hypotheses across multiple biological contexts.

bioRxiv · Jun 18, 2019 · PreprintEvolutionary Biology