Z. He

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

This study shows Hsp27 binds phosphorylated Tau to prevent its aggregation and mitigate AD pathology.

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

This study develops a stromal tumoroid model of pancreatic cancer to investigate cell interactions and state changes, identifying key factors like SDC1 and PPARG that influence cancer cell behavior and therapy response.

This study combines emodin with low-frequency low-intensity ultrasound to treat osteomyelitis by enhancing antibacterial and anti-biofilm effects through sonoantimicrobial chemotherapy.

This study identifies the APC/CTAD1-WL1-NAL1 pathway as a regulator of leaf width in rice and shows that mutations in WL1 lead to leaf width variation.

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

The paper introduces a time-resolved statistical method to analyze the evolutionary dynamics of SARS-CoV-2 spike mutations and quantifies mutation strength using the L-index.

This paper investigates the concordance between two methods for detecting positive selection and finds that they often disagree, suggesting negative selection variation may mislead positive selection inferences.

This study examines sieve tube structural variation in Austrobaileya scandens, finding small sieve plate pore radii and hydraulic segmentation that may affect energy distribution in lianas.

This study constructs a ceRNA network in metastatic melanoma to identify prognostic markers and therapeutic targets, finding miR-3662 may be used in treatment.

This paper introduces a 3D bioprinting technique called DASP to create mechanically robust, multiscale porous scaffolds for encapsulating human pancreatic islets to enable responsive insulin release.

This study examines how acute isolation affects vocal and non-vocal social behaviors in male and female mice during same-sex and opposite-sex interactions, finding stronger effects in females.

This study investigates how age-matching between fecal microbiota transplantation (FMT) donors and aged recipients affects microbiota establishment and resilience, finding that mismatched age may reduce resilience against inflammation.

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

This study shows platinum nanoparticles reduce intracellular reactive oxygen species and protect cells from cold atmospheric plasma-induced cytotoxicity in both cancerous and non-cancerous cell lines.

The paper tests the synergistic anti-cancer effects of pyrazolopyrimidinones combined with cold atmospheric plasma against glioblastoma cells and identifies two prodrugs that show enhanced cytotoxicity in combination.

This study identifies unreported memory retrievals in free recall tasks by analyzing inter-response times, revealing three distinct silent effects and proposing a minimal model to explain them.

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

This study validates a new associative transcriptomics pipeline in Brassica oleracea to identify vernalisation response candidates, finding miR172D and BoFLC.C2 as potential markers.

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

This study identifies bacterial swarmers as protective against intestinal inflammation in mice and humans, showing their ability to enrich beneficial gut microbes.

This paper introduces a method to identify microbiome features affecting outcomes while controlling for confounding variables, showing improved accuracy in agricultural microbiome studies.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This paper develops a whole-cell biosensor to detect DAPG-producing bacteria in grassland soil, showing high sensitivity and enabling isolation and population dynamics analysis.

This study shows microglia regulate retinal capillary constriction via fractalkine-Cx3cr1 signaling and RAS pathway, with dysfunction occurring early in diabetic retinopathy.

The paper identifies compounds that inhibit SARS-CoV-2 3CLpro enzyme activity, with auranofin showing strong inhibition and potential for COVID-19 treatment.

The paper re-examines evidence for adaptive DNA sequence evolution using MK and PAML tests on Drosophila and Arabidopsis data, finding little overlap and suggesting unreliable results.