Masud Husain B

A hippocampal neuroimaging signature of neurovascular insulin signalling links metabolism to mood

The paper identifies a hippocampal metabolic signature linked to mood and insulin signalling in depression, showing conserved effects across humans and mice.

Transsaccadic working memory in healthy ageing and neurodegenerative disease

This study investigates how spatial and colour information is updated across saccades in healthy ageing and neurodegenerative diseases, finding that spatial memory is selectively impaired.

Human whole-epigenome modelling for clinical applications with Pleiades

Pleiades, a whole-genome epigenetic model, detects Alzheimer's and Parkinson's disease from plasma cell-free DNA with high accuracy.

A computational approach to understanding effort-based decision-making in depression

This study identifies four computational mechanisms underlying effort-based decision-making in depression and finds that remitted and current depressed individuals show reduced effort acceptance bias.

Working memory as a representational template for reinforcement learning

This study investigates how working memory (WM) representation formats influence reinforcement learning (RL) by manipulating whether features or objects are remembered and measuring their impact on learning outcomes.

Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making

The paper examines neural oscillations in human basal ganglia and prefrontal cortex during decision-making tasks, finding distinct roles for beta and theta oscillations in tracking effort and previous reward.

Effects of focal epilepsy and aging on discrimination and reactivation of memories

This study introduces a behavioral task to measure pattern separation and completion, showing deficits in pattern completion in focal epilepsy and degraded pattern separation in aging.

Hypersensitivity to uncertainty is key feature of subjective cognitive impairment

This study shows that individuals with subjective cognitive impairment (SCI) are hypersensitive to uncertainty, which correlates with affective symptoms like depression and anxiety, and is linked to insular-hippocampal connectivity.

Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action

This study investigates the role of D1 receptors in the nucleus accumbens core in regulating reward-seeking behavior during Go/No-Go tasks in rats.

5-HT2C receptor perturbation has bidirectional influence over instrumental vigour and restraint

This study examines how 5-HT2C receptor perturbation affects instrumental vigour and restraint in rats, finding that systemic activation boosts performance and reduces restraint, while dopamine enhances restraint and action initiation.

Distinct neural representations for prosocial and self-benefitting effort

The paper identifies distinct neural representations for prosocial and self-benefitting effort using fMRI and shows empathy correlates with prosocial effort encoding.

Ageing disrupts reinforcement learning whilst learning to help others is preserved

This study shows that older adults maintain prosocial learning rates but have reduced self-relevant learning rates compared to younger adults.

Reduced cortico-muscular beta coupling in Parkinsons disease predicts motor impairment

This study shows reduced cortico-muscular beta coupling in Parkinson's disease patients predicts motor impairment despite comparable grip strength.

Neural signatures of pathological hyperdirect pathway activity in Parkinson's disease

The paper identifies signatures of the hyperdirect pathway and its role in pathological network disruption in Parkinson's disease through multimodal analysis.

Dopamine modulates dynamic decision-making during foraging

This study shows dopamine modulates decision-making during foraging by influencing background reward rates rather than foreground rewards.

Spatial distribution and cognitive impact of cerebrovascular risk-related white matter hyperintensities

This study investigates the spatial distribution of white matter hyperintensities (WMHs) related to cerebrovascular risk factors and their impact on cognitive function in a large cohort.

Automated lesion segmentation with BIANCA: impact of population-level features, classification algorithm and locally adaptive thresholding

This paper improves the BIANCA tool for WMH segmentation by introducing a locally adaptive thresholding method, LOCATE, which significantly enhances segmentation performance compared to global thresholding.

A neural model of working memory

This paper proposes a unified neural model of working memory that integrates self-sustained neural firing and activity-silent synaptic traces to explain attention and memory effects.

Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank

The paper derives age-related normative percentiles for hippocampal and grey matter volume using UK Biobank data to aid in clinical and research assessments of brain health.

Parallel encoding of information into visual short-term memory

The paper shows that information from multiple objects can be encoded into visual short-term memory in parallel, challenging the traditional serial encoding assumption.