Stefania Marcotti

A glucosylcholesterol-cytoskeleton axis links GBA2 loss-of-function to synaptic and mitochondrial pathology in Hereditary Spastic Paraplegia

This study identifies a GlcChol-RAC1-actin signaling axis linking GBA2 loss-of-function to synaptic and mitochondrial dysfunction in SPG46, with Rac1 inhibition rescuing disease phenotypes in a zebrafish model.

Advanced in High-Resolution Cryo Volume Electron Microscopy (cvEM) Imaging for Unicellular and Multicellular Organisms

This paper improves cryo-volume Electron Microscopy (cvEM) techniques for imaging whole cells and tissues, demonstrating enhanced resolution using Caenorhabditis elegans and Paramecium bursaria.

Spatially distinct chromatin compaction states predict neoadjuvant chemotherapy resistance in Triple Negative Breast Cancer

The paper uses FLIM to measure chromatin compaction in TNBC tissues and finds that spatial chromatin states predict resistance to neoadjuvant chemotherapy.

Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction

This study examines how Tau35 protein affects lysosomal function and autophagy, identifying early pathological changes linked to neurotoxicity in tauopathies.

Blocking mechanical airway epithelia damage during asthma progression reverses airway remodelling and hyperresponsiveness

This study shows that blocking mechanical damage in airway epithelia during asthma reverses airway remodelling and hyperresponsiveness, suggesting asthma may be curable.

SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast Cancer

The paper introduces SMART, a spatio-molecular atlas of TNBC response trajectories, revealing distinct epithelial archetypes and tumor-immune microenvironments associated with treatment response and prognosis.

A Statistical Framework for Robust and Reproducible BioImage Analysis

This study reanalyzes image datasets to emphasize robust experimental design and effect sizes over statistical significance, providing open-access code to improve reproducibility.

GliaMorph: A modular image analysis toolkit to quantify Müller glial cell morphology

GliaMorph quantifies Müller glial cell morphology across developmental and disease states, revealing structural changes and subcellular features in zebrafish and mouse models.

Extracellular matrix assembly stress drives Drosophila central nervous system morphogenesis

This study shows that extracellular matrix assembly stress actively drives morphogenesis in Drosophila ventral nerve cord by generating surface tension during collagen-IV network formation.