Thuc Nghi Nguyen

A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

This paper creates a high-resolution transcriptomic and spatial cell type atlas of the whole adult mouse brain, revealing spatial organization and transcription factor codes for cell types.

Dense Functional and Molecular Readout of a Circuit Hub in Sensory Cortex

The paper combines calcium imaging and spatial transcriptomics to study functional and molecular properties of neuronal subclasses in the somatosensory cortex during a tactile working memory task.

A multimodal cell census and atlas of the mammalian primary motor cortex

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

An integrated transcriptomic and epigenomic atlas of mouse primary motor cortex cell types

The paper creates a comprehensive atlas of mouse primary motor cortex cell types using integrated transcriptomic and epigenomic data from over 600,000 samples.

Single-cell RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates and humans

The paper uses single-cell RNA-seq to analyze relay neurons in the dLGN across species, finding subtle transcriptomic differences compared to morphological and functional distinctions.

Characterization of a fiber-coupled EvenField illumination system for fluorescence microscopy

The paper characterizes fiber-coupled illumination systems for fluorescence microscopy, comparing speckle reduction schemes and introducing a new design called the EvenField Illuminator.

Cell segmentation-free inference of cell types from in situ transcriptomics data

This paper introduces SSAM, a cell segmentation-free method for cell-type identification and tissue domain detection in in situ transcriptomics data, showing it detects known and discovers new cell types in mouse brain tissues.

A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

This study defines a comprehensive transcriptomic cell type taxonomy of the adult mouse isocortex and hippocampal formation using single-cell RNA-sequencing.

Regional, layer, and cell-class specific connectivity of the mouse default mode network

This study identifies the anatomical composition and connectivity patterns of the mouse default mode network at the regional, layer, and cell-class levels.

Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types

Complete morphologies of 1,708 neurons, sparsely labelled and imaged whole-brain with fMOST, expose region-specific long-range projection rules and finer diversity than current transcriptomic subtypes capture.

Distinct transcriptomic cell types and neural circuits of the subiculum and prosubiculum along the dorsal-ventral axis

The paper identifies 27 transcriptomic cell types in mouse subiculum and prosubiculum, defines their anatomical boundaries, and reveals distinct neural circuits and projections along the dorsal-ventral axis.

Enhancer viruses and a transgenic platform for combinatorial cell subclass-specific labeling

The paper develops enhancer viruses and a transgenic mouse line to enable combinatorial labeling of specific neuronal subclasses in the mouse cortex and human slices.

Conserved cell types with divergent features between human and mouse cortex

The paper compares cell types in human and mouse cortex using single nucleus RNA-sequencing, finding conserved architecture with species-specific differences.

Classification of electrophysiological and morphological types in mouse visual cortex

The paper classifies neurons in mouse visual cortex into 17 electrophysiological and 35 morphological types using unsupervised methods and links them to transcriptomic types.

Multimodal cell type correspondence by intersectional mFISH in intact tissues

The paper presents a method combining spatial transcriptomics with optogenetic mapping to resolve cell type characteristics in mouse cortex.

Equivalent high-resolution identification of neuronal cell types with single-nucleus and single-cell RNA-sequencing

The paper shows that single-nucleus and single-cell RNA-seq can equally identify neuronal cell types in mouse visual cortex when intronic sequences are included.

Distinct descending motor cortex pathways and their roles in movement

The paper identifies two types of motor cortex neurons with distinct roles in movement preparation and execution using single-cell profiling and axonal reconstructions.

Shared and distinct transcriptomic cell types across neocortical areas

The paper identifies shared and distinct transcriptomic cell types in two mouse neocortical regions using scRNA-seq, showing most excitatory types are region-specific while inhibitory types are shared.

A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality

The paper introduces a new set of transgenic mouse lines for precise targeting and manipulation of brain cell types, enhancing genetic tools for neuroscience research.