Hiren Jitendra Joshi

Inward and Outward Tethers Read Out the Spontaneous Curvature of Cellular Membranes

This paper introduces a method to measure spontaneous curvature in cellular membranes using tether pulling and simulations, revealing baseline negative curvature and its modulation by treatments.

Structure and mechanism of the human TMEM260 O-mannosyltransferase

This study determines the cryo-EM structure of human TMEM260, revealing its mechanism for O-mannosylation of key receptors and providing insights into related congenital disorders.

O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis

The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.

High-throughput and scalable single cell proteomics identifies over 5000 proteins per cell

This study improves single-cell proteomics by increasing protein identification from ~2000 to over 5000 per cell and enhancing throughput and reliability.