This study shows Rad18 suppresses 4NQO-induced oral carcinogenesis but not KrasG12D-driven lung tumors, highlighting context-specific tumor-suppressive roles.

NAR Cancer · Jan 7, 2026Peer-reviewedCancer Biology

The RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling

Lilly F. Chiou, Gaith N. Droby, Deepika Jayaprakash, Jay Ramanlal Anand, Xingyuan Zhang, Yang Yang, Christine A. Mills, Thomas S. Webb, Natalie K. Barker, Jialiu Xie, Di Wu, Laura E. Herring, Junya Tomida, Jessica L. Bowser, Cyrus Vaziri

This study identifies RNF25's role in protecting DNA replication forks from degradation, independent of its ubiquitin signaling functions.

Nature Communications · Aug 5, 2025Peer-reviewedMolecular Biology

CD38⁺ Endothelial Remodeling Defines Spatially Diverse Vasculopathy Programs in Rapidly Advancing Oral Inflammation

Quinn T. Easter, Khoa Huynh, Camila S. Stolf, Jialiu Xie, Bruno Fernandes Matuck, Akira Hasuike, Zabdiel Alvarado‐Martinez, Zhaoxu Chen, Apoena Aguiar Ribeiro, Nivedita Pareek, M. Andrea Azcárate-Peril, Di Wu, Renato Côrrea Viana Casarin, Kang I. Ko, Jinze Liu, Kevin M. Byrd

The paper identifies CD38⁺ endothelial remodeling as a spatially distinct vasculopathy feature in rapidly advancing oral inflammation using scRNA-seq and spatial proteomics.

bioRxiv · Jul 29, 2025 · PreprintImmunology

Deep-learning-based interpolation of longitudinal microbiome data powers biologically informative discovery

Yixiang Qu, Ruiqi Lyu, Duan Wang, Yifan Dai, Alistair Turcan, Shilin Yu, Jialiu Xie, Jeffrey M. Roach, Catherine A. Butler, Pew‐Thian Yap, Hongtu Zhu B, Stuart G. Dashper, Apoena Aguiar Ribeiro, Didong Li, Kimon Divaris, Di Wu

This paper introduces BGOB, a deep learning framework for longitudinal microbiome interpolation, improving analysis of microbial community trajectories and revealing disease-related associations.

bioRxiv · Feb 17, 2025 · PreprintMicrobiology

Longitudinal Microbiome-based Interpretable Machine Learning for Identification of Time-Varying Biomarkers in Early Prediction of Disease Outcomes

Yifan Dai, Yunzhi Qian, Yixiang Qu, Wyliena Guan, Jialiu Xie, Duan Wang, Catherine A. Butler, Stuart G. Dashper, Ian M. Carroll, Kimon Divaris, Yufeng Liu, Di Wu

This paper introduces LP-Micro, a machine learning framework for analyzing longitudinal microbiome data to identify time-varying biomarkers predictive of disease outcomes.

bioRxiv · Oct 18, 2024 · PreprintBioinformatics

Inhibition of Androgen Receptor Exposes Replication Stress Vulnerability in Prostate Cancer

C Williams, Xin Li, Hongjun Jang, Jay Ramanlal Anand, Won Young Lim, Hyejin Lee, Julie Parks, Xingyuan Zhang, Jialiu Xie, Jinshi Zhao, Di Wu, Andrew J. Armstrong, Jessica L. Bowser, Lee Zou, Jiyong Hong, , Pei Zhou

The paper shows that AR inhibition in prostate cancer causes DNA replication stress, which can be exploited by combining with a TLS inhibitor to enhance treatment efficacy.

bioRxiv · Oct 8, 2024 · PreprintCancer Biology