Toren Finkel

Characterizing Cellular Heterogeneity and Transcriptomic Features of Senotype Using Deep Graph Representation Learning

This paper introduces DeepSAS, a deep graph framework to identify senescent cells and their associated genes, revealing cell-type-specific senescence features in aging and disease.

Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation

This study identifies high-risk mesenchymal stem cells (hrMSCs) that drive DNA damage and promote high-grade serous ovarian cancer initiation in fallopian tube epithelium.

SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms

The paper develops SenSet, a gene signature for human lung senescence, validated in 3D culture models and identifies cell-type specific senescence mechanisms in aging and disease.

Hypomorphic NOTCH1 Expression Alters Cardiomyocyte Cellular Architecture in Hypoplastic Left Heart Syndrome

This paper uses CRISPR-edited human iPSCs with hypomorphic NOTCH1 to model hypoplastic left heart syndrome, identifying auranofin as a potential therapeutic.