Author

Mason R. Mackey

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:electronic health records· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Mark H. EllismaniD· 4 shared Stephen AdamsiD· 3 shared Junru HuiD· 2 shared Keun-young Kim AiD· 2 shared Ranjan RamachandraiD· 2 shared Steven T. Peltier· 2 shared Aaron T. KuaniD· 1 shared Alice Y. TingiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersNeuroscience

Mark H. EllismanORCID

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Author profile →

4 papers

Recent·Most cited

Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

Song-Yi Lee, Heegwang Roh, David González-Pérez, Mason R. Mackey, Daniel Hoces, Colleen N. McLaughlin, Chang Lin, Stephen Adams, Khanh Hung Nguyen, Keun-young Kim A, David J. Luginbuhl, Liqun Luo, Namrata D. Udeshi, Steven A. Carr, Rogelio Antonio Hernández-López, , Alice Y. Ting

This study evolves a laccase enzyme for cell surface labeling and EM, showing it can map T cell surface changes and visualize cell features without toxic H2O2.

Nature Chemical Biology · Aug 1, 2025Peer-reviewedBiochemistry

Scalable electron tomography for connectomics

Aaron T. Kuan, Sébastien Phan, Keun-young Kim A, Mason R. Mackey, Minsu Kim, Steven T. Peltier, Mark H. Ellisman, Wei-Chung Allen Lee

This paper demonstrates limited-tilt serial section electron tomography for high-resolution 3D mapping of brain circuits and evaluates imaging parameters for connectomic-scale projects.

bioRxiv · Jun 5, 2024 · PreprintNeuroscience

Elemental Mapping of Labeled Biological Specimens at Intermediate Energy Loss in an Energy-Filtered TEM acquired using a Direct Detection Device

Ranjan Ramachandra, Mason R. Mackey, Junru Hu, Steven T. Peltier, Nguyen‐Huu Xuong, Mark H. Ellisman, Stephen Adams

The paper demonstrates improved signal-to-noise and resolution in EFTEM elemental mapping by using lower energy-loss N4,5 edges instead of core-loss M4,5 edges for lanthanide detection.

Journal of Microscopy · Apr 12, 2021Peer-reviewedSystems Biology

A genetic probe for visualizing glutamatergic synapses and vesicles by 3D electron microscopy

Thomas Steinkellner, Matthew Madany, Matthias Georg Haberl, Vivien Zell, Carolina Li, Junru Hu, Mason R. Mackey, Ranjan Ramachandra, Stephen Adams, Mark H. Ellisman, Thomas S. Hnasko, Daniela Boassa

The paper develops a genetic probe to label and image glutamatergic synaptic vesicles using 3D electron microscopy and deep learning.

ACS Chemical Neuroscience · Feb 1, 2021Peer-reviewedNeuroscience