Author

Kottapalli Srividya

Central Drug Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aamir NaziriD· 2 shared Aamir NaziriD· 1 shared Aayushi Agrawal· 1 shared Anil KouliD· 1 shared Ankur GautamiD· 1 shared Arpit GuptaiD· 1 shared Arpit MehrotraiD· 1 shared Arunabh SarkariD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersGenetics

Aamir NazirORCID

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Author profile →

4 papers

Recent·Most cited

T13F2.2 of C. elegans is Critical for Chromatin Organization, Autophagy, and Longevity

Rohil Hameed, Sweta Sikder, Aayushi Agrawal, Kottapalli Srividya, Kalyan Mitra, Madavan Vasudevan, Parijat Senapati, Aamir Nazir, Tapas Kumar Kundu

This study identifies T13F2.2 as a critical gene in C. elegans that affects chromatin structure, autophagy, and lifespan through RNAi depletion and transcriptomic analysis.

bioRxiv · Sep 22, 2025 · PreprintGenetics

Changes in microglia chromatin accessibility in aged female mice.

Victor A. Ansere, Kyla B. Tooley, Kottapalli Srividya, Walker Hoolehan, Kevin D. Pham, Sarah R. Ocañas, Willard M. Freeman

This study identifies age-related changes in chromatin accessibility in female microglia, showing more gains than losses in accessibility, enriched in immune-related genes and intergenic regions.

bioRxiv · Jan 18, 2024 · PreprintMolecular Biology

Penetratin inhibits α-synuclein fibrillation and improves locomotor functions in mice model of Parkinsons disease

Arpit Gupta, Priyanka Singh, Arpit Mehrotra, Ankur Gautam, Kottapalli Srividya, Rajlaxmi Panigrahi, Shubham Vashishtha, Jasdeep Singh, Gagandeep Jaiswal, Krishna Upadhayay, Signe Andrea Frank, Janni Nielsen, Samir Kumar Nath, Neeraj Khatri, Daniel E. Otzen, , Deepak Sharma

This study identifies penetratin as an inhibitor of α-synuclein aggregation and shows it improves locomotor function in Parkinson's disease mouse models.

bioRxiv · Jun 24, 2022 · PreprintNeuroscience

Targeted downregulation of estradiol binding Na+/H+ exchanger nhx-2, mimics calorie restriction, extends reproductive longevity and ameliorates effects associated with alpha synuclein aggregation in C. elegans

Shikha Shukla, Lalit Kumar, Arunabh Sarkar, Kottapalli Srividya, Aamir Nazir

This study identifies nhx-2 as a modulator that extends reproductive longevity and ameliorates alpha-synuclein aggregation effects in C. elegans by mimicking dietary restriction.

bioRxiv · Jul 30, 2020 · PreprintNeuroscience