Geoffrey Liu

Revealing the Drivers Underlying Distinct Evolutionary Trajectories in Lung Adenocarcinoma

This study identifies three distinct evolutionary trajectories in lung adenocarcinomas using whole-genome sequencing, revealing that some never-smoking tumors follow smoking-like paths driven by KRAS mutations.

Cross-ancestral GWAS identifies 29 novel variants across Head and Neck Cancer subsites

This study conducts a cross-ancestral GWAS and fine mapping of head and neck squamous cell carcinoma subsites, identifying 29 novel variants and highlighting gene-environment interactions.

A prognostic signature for lung adenocarcinoma in people who have never smoked

The paper identifies three subtypes of NS-LUAD using RNA-seq data and develops a 60-gene signature that predicts survival across subgroups.

Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition

This study analyzes 1024 lung adenocarcinomas to identify evolutionary patterns and mutational mechanisms, revealing distinct trajectories linked to smoking, ancestry, and retrotransposition.

Two-Stage Multivariate Mendelian Randomization on Multiple Outcomes with Mixed Distributions

The paper introduces a two-stage multivariate Mendelian Randomization method to analyze mixed distributed outcomes with instrumental variables, showing improved statistical power in simulations and a clinical trial.

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

This study uses Mendelian randomization to assess the causal effect of sexual behavior on oropharyngeal cancer risk, finding attenuated associations after adjusting for confounders.

KuLGaP: A Selective Measure for Assessing Therapy Response in Patient-Derived Xenografts

The paper introduces KuLGaP, a selective measure to assess therapy response in patient-derived xenografts by comparing treatment and control arms, improving accuracy over existing methods.

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

The paper identifies genetic links between impaired pulmonary function and increased lung cancer risk, showing causal relationships through Mendelian randomization and highlighting immune-related pathways.