Thomas Rülicke

Large neutral amino acid levels tune perinatal neuronal excitability and survival

The paper investigates how changes in large neutral amino acid metabolism during development affect neuronal excitability and survival, finding that Slc7a5 deletion disrupts lipid metabolism and leads to long-term circuit dysfunction.

Recurrent impairments in visual perception and place avoidance across autism models are causally linked in the haploinsufficiency model of intellectual disability Setd5

The paper identifies a shared visual perception and place avoidance deficit in ASD models, linked to Kv1 channel hypoexcitability in the dPAG, and shows pharmacological rescue of these deficits.

Tissue-wide Effects Overrule Cell-intrinsic Gene Function in Cortical Projection Neuron Migration

This study shows that tissue-wide genetic effects override cell-intrinsic gene function in cortical neuron migration using MADM and single-cell analysis.

A Genome-wide Library of MADM Mice for Single-Cell Genetic Mosaic Analysis

The paper introduces a genome-wide MADM mouse library enabling single-cell genetic mosaic analysis and uses it to study chromosome-specific segregation biases in stem cell division.

GluD2- and Cbln1-mediated Competitive Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells

This study shows that GluD2 and Cbln1 mediate competitive synaptogenesis, shaping Purkinje cell dendritic arbors in the cerebellum through competitive synapse formation.