Author

Oliver Wirths

Universitätsmedizin GöttingenORCID 0000-0002-4115-0334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Andrew Octavian SasmitaiD· 2 shared Bárbara MorgadoiD· 2 shared Constanze DeppiD· 2 shared Gesine SaheriD· 2 shared Hans‐Wolfgang KlafkiiD· 2 shared Jens WiltfangiD· 2 shared Katharina Overhoff· 2 shared Klaus‐Armin NaveiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Andrew Octavian SasmitaORCID

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3 papers

Recent·Most cited

Aggregation-Dependent Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies

Ivan Talucci, Timon Leske, Hans‐Wolfgang Klafki, Hassan Mohammed Mehedi, Steiert Annik, Bárbara Morgado, Sebastian Bothe, van Werven Lars, Thomas Liepold, Jochen Walter, Hermann Schindelin, Jens Wiltfang, Oliver Wirths, Olaf Jahn, Hans Michael Maric

This study characterizes the binding and modification requirements of 20 anti-Aβ antibodies across different Aβ forms, revealing aggregation-dependent sequence and modification selectivity.

eLife · Feb 9, 2026Peer-reviewedBiochemistry

Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer's disease

Andrew Octavian Sasmita, Constanze Depp, T. I. Nazarenko, Ting Sun, Sophie B. Siems, Erinne Cherisse Ong, Yakum Bertrand Nkeh, Carolin Böhler, Xuan Yu, Bastian Bues, Lisa Evangelista, Shuying Mao, Bárbara Morgado, Zoe Y. Wu, Torben Ruhwedel, , Klaus‐Armin Nave

The paper shows oligodendrocytes contribute to amyloid-β plaques in Alzheimer's disease, but neurons are required for plaque formation.

Nature Neuroscience · Aug 5, 2024Peer-reviewedNeuroscience

Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer's disease

Constanze Depp, Ting Sun, Andrew Octavian Sasmita, Lena Spieth, Stefan A. Berghoff, T. I. Nazarenko, Katharina Overhoff, Agnes A. Steixner-Kumar, Swati Subramanian, Sahab Arinrad, Torben Ruhwedel, Wiebke Möbius, Sandra Göbbels, Gesine Saher, Hauke B. Werner, , Klaus‐Armin Nave

This study shows that ageing-related myelin dysfunction drives amyloid-beta deposition in Alzheimer's disease mouse models, suggesting myelin integrity as an upstream risk factor.

Nature · May 31, 2023Peer-reviewedNeuroscience