Author

David E. Clapham

Howard Hughes Medical InstituteORCID 0000-0002-4459-9428Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

David E. Clapham1 paper

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Organism:Drosophila· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Abraham G. BeyeneiD· 1 shared Alison N. KillileaiD· 1 shared Alyson PetruncioiD· 1 shared Andrew S. MooreiD· 1 shared Andrew T. KrasleyiD· 1 shared Aubrey V. WeigeliD· 1 shared Ben Cristofori‐ArmstrongiD· 1 shared Benjamin L. MartiniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperNeuroscience

Abraham G. BeyeneORCID

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3 papers

Recent·Most cited

A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms

Tian-ming Fu B, Gaoxiang Liu, Daniel Edward Milkie, Xiongtao Ruan, Frederik Görlitz, Yu Shi, Valentina Ferro, Nikita S. Divekar, Wei Wang, Harrison M. York, Velat Kilic, Matthew Mueller, Yajie Liang, Timothy A. Daugird, María José Gacha Garay, , Srigokul Upadhyayula

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

Nature Methods · May 22, 2026Peer-reviewedCell Biology

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Lorena Benedetti, Ruolin Fan, Aubrey V. Weigel, Andrew S. Moore, Patrick R. Houlihan, Mark Kittisopikul, Grace Park, Alyson Petruncio, Philip M. Hubbard, Song Pang, C. Shan Xu, Harald F. Hess, Stephan Saalfeld, Vidhya Rangaraju, David E. Clapham, , Jennifer Lippincott‐Schwartz

The paper identifies periodic ER-PM junctions in dendrites that enable long-range Ca2+ signal integration through local spine activation and ryanodine receptor-dependent Ca2+ release.

Cell · Dec 20, 2024Peer-reviewedNeuroscience

Visualizing Synaptic Dopamine Efflux with a 2D Nanofilm

Chandima Bulumulla, Andrew T. Krasley, Ben Cristofori‐Armstrong, William C. Valinsky, Deepika Walpita, David Ackerman, David E Clapham, Abraham G. Beyene

This paper introduces a 2D nanofilm to visualize dopamine release with synaptic resolution and quantal sensitivity, revealing spatial patterns and colocalization with Bassoon in dendrites.

eLife · Jul 4, 2022Peer-reviewedNeuroscience