This study uses machine learning to predict alcohol-related memory problems in older adults by integrating multi-domain features including brain connectivity, polygenic risk, and lifestyle factors.

bioRxiv · Dec 30, 2022 · PreprintNeuroscience

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

Emma C. Johnson, Manav Kapoor, Alexander Samir Hatoum, Hang Zhou, Renato A Polimanti, Frank R. Wendt, Raymond Kenney Walters, Dongbing Lai, Rachel L. Kember, Sarah M. Hartz, Jacquelyn Leigh Meyers, Roseann Elizabeth Peterson, Stephan Ripke, Tim B. Bigdeli, Ayman H. Fanous, , Arpana Agrawal A

This study identifies genetic variants shared between schizophrenia and alcohol use disorder, finding both convergent and divergent effects and evidence of brain tissue expression.

Psychological Medicine · Jul 7, 2021Peer-reviewedGenetic & Genomic Medicine

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

Renato A Polimanti, Raymond Kenney Walters, Emma C. Johnson, Jeanette N. McClintick, Amy E. Adkins, Daniel E. Adkins, Silviu‐Alin Bacanu, Laura Jean Bierut, Tim B. Bigdeli, Sandra A. Brown, Kathleen Keenan Bucholz, William Copeland, E. Jane Costello, Louisa J Degenhardt, Lindsay A. Farrer, , Joel E. Gelernter

The paper compares genome-wide data from opioid use and dependence cases to identify genetic associations and differences between exposure and dependence.

Molecular Psychiatry · Feb 25, 2020Peer-reviewedGenetics

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Raymond Kenney Walters, Renato A Polimanti, Emma C. Johnson, Jeanette N. McClintick, Mark J. Adams, Amy E. Adkins, Fazil Alıev, Silviu‐Alin Bacanu, Anthony J. Batzler, Sarah E. Bertelsen, Joanna M. Biernacka, Tim B. Bigdeli, Li‐Shiun Chen, Toni‐Kim Clarke, Yi‐Ling Chou, , Norbert Wodarz

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.

Nature Neuroscience · Nov 19, 2018Peer-reviewedGenetics

Genome-wide analysis of risk-taking behaviour and cross-disorder genetic correlations in 116,255 individuals from the UK Biobank cohort

Rona J. Strawbridge, Joey Ward, Breda Cullen, Elizabeth M. Tunbridge, Sarah M. Hartz, Laura Jean Bierut, Amy C. Horton, Mark E.S. Bailey, Nicholas Graham, Amy Ferguson, Donald M. Lyall, Daniel Mackay, Laura M. Pidgeon, Jonathan Cavanagh, Jill P. Pell, , Daniel J. Smıth

This study identifies genetic loci associated with risk-taking behavior and finds shared genetic risk with several psychiatric and physical disorders using UK Biobank data.

Translational Psychiatry · Feb 1, 2018Peer-reviewedGenetics

Association Between Substance Use Disorder And Polygenic Liability To Schizophrenia

Sarah M. Hartz, Amy C. Horton, Mary E. Oehlert, Caitlin E. Carey, Arpana Agrawal A, Ryan Bogdan, Li‐Shiun Chen, Dana B. Hancock, Eric Otto Johnson, Carlos N. Pato, Michele T. Pato, John P. Rice, Laura Jean Bierut

The paper investigates the genetic link between schizophrenia and substance use disorder, finding shared polygenic liability across multiple datasets.

Biological Psychiatry · Jun 6, 2017Peer-reviewedGenetics