Sam J. Wilson

Alternative splicing broadens antiviral diversity at the human OAS2 locus

The paper shows that alternative splicing of the OAS2 gene generates two antiviral proteins with distinct target specificities and mechanisms.

Oncolytic Reovirus mediates innate-driven SARS-CoV-2 elimination in the absence of cell toxicity

This paper shows that oncolytic Reovirus can eliminate SARS-CoV-2 in lung cells without causing toxicity by enhancing innate antiviral responses.

Multi-omics analysis of virus-permissive versus hostile cellular states reveals protein networks controlling virus infection

The paper identifies protein networks associated with virus-permissive and hostile cellular states through multi-omics analysis, revealing discrepancies between mRNA and protein levels and the role of phosphorylation in infection control.

Meta-analysis of virus-induced host gene expression reveals unique signatures of immune dysregulation induced by SARS-CoV-2

This study performs a meta-analysis of transcriptomics data to identify immune dysregulation signatures in SARS-CoV-2 infection, linking gene expression patterns to patient age and disease severity.

Improvements to the ARTIC multiplex PCR method for SARS-CoV-2 genome sequencing using nanopore

V3 primer pools with 22 extra alternates improve coverage; revised library preps raise double-barcode demultiplexing from 42.15% to 74.5%, cut misassignment 35x and bring reagent cost near £10 per sample.