Christophe Tzourio

Resting State connectivity patterns associated with trait anxiety in adolescence

The paper investigates resting-state connectivity patterns in adolescents with trait anxiety, finding reduced connectivity in networks related to self-referential processing and rumination.

Early detection of white matter hyperintensities using SHIVA-WMH detector

The paper introduces a deep learning tool, SHIVA-WMH, for detecting white matter hyperintensities across different WMH severities and demonstrates its superior performance compared to existing methods.

Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics

This paper uses genetic data to investigate the causal relationships between vascular traits like white matter hyperintensity, blood pressure, and stroke with dementia and Alzheimer's disease risk.

Drowsiness during resting-state fMRI: a major confounder of functional connectivity

This paper investigates how drowsiness affects functional connectivity in resting-state fMRI and finds that correction methods can reduce its impact, but no single method is optimal.

Changes in regional white matter volumetry and microstructure during the post-adolescence period: a cross-sectional study of a cohort of 1,713 university students

This study examines regional changes in white matter volume and microstructure in young adults using MRI data from 1,713 university students, revealing age-related variations in microstructural properties.

The MRi-Share database: brain imaging in a cross-sectional cohort of 1,870 university students

The paper introduces the MRi-Share database, a multi-modal brain MRI dataset of 1,870 young adults, and presents preliminary findings on age and sex associations with brain phenotypes.

3D segmentation of perivascular spaces on T1-weighted 3 Tesla MR images with a convolutional autoencoder and a U-shaped neural network

This paper develops a deep learning algorithm for 3D segmentation of perivascular spaces in MRI data, achieving high accuracy and demonstrating interoperability across scanners.

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

Deep learning-based classification of resting-state fMRI independent-component analysis

The paper develops a deep learning classifier to assign independent components from resting-state fMRI to predefined resting-state networks, achieving 92% accuracy and creating an RSN atlas.

Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

This study examines age-related changes in PSMD across the adult lifespan using multi-cohort diffusion tensor imaging data, finding PSMD increases consistently while other metrics show different age patterns.

The Genetic History of France

This study analyzes SNP-chip data from 2,184 French individuals to identify genetic clusters, detect gene flow barriers, and estimate population size changes, revealing historical demographic patterns.

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

Planar cell polarity pathway and development of the human visual cortex

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.