Jean-Rémy Sadeyen

Bovine H5N1 influenza viruses have adapted to more efficiently use receptors abundant in cattle

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

The mammalian-adaptive PB2-E627K substitution preserves viral fitness of clade 2.3.4.4b H5N1 HPAIV in birds.

This study shows that the mammalian-adaptive PB2-E627K mutation in H5N1 HPAIV maintains viral fitness in avian hosts, increasing zoonotic risk.

Emerging Haemagglutinin Mutations in Bovine-origin H5N1 Influenza Viruses from Humans and Cattle Retain Avian Receptor Binding with Increased Stability

This study examines HA mutations in bovine-origin H5N1 influenza viruses, finding they retain avian receptor binding but show increased HA stability, potentially raising zoonotic risk.

Mutations in severe human H5N1 cases facilitate evasion from human mucus and antivirals

This study examines mutations in H5N1 influenza virus HA that affect receptor binding and antiviral susceptibility, finding reduced sialic acid binding correlates with mucus evasion and antiviral resistance.

The canine respiratory epithelium is a permissive ecosystem for influenza interspecies transmission and emergence

This study shows that the canine respiratory tract supports influenza A virus replication and could facilitate interspecies transmission and emergence of new IAVs.

Prior infection with IBDV prolonged the shedding of a mallard H3N8 influenza A virus (IAV) challenge from the oropharyngeal cavity of some chickens and increased the number of amino acid substitutions in the IAV samples

This study shows that prior IBDV infection in chickens increases IAV replication, prolongs viral shedding, and raises amino acid substitutions in mallard H3N8 IAV.

Mapping Haemagglutinin Residues Driving Antigenic Diversity in H5Nx Avian Influenza Viruses

This study identifies key HA residues driving antigenic diversity in H5Nx avian influenza viruses through serology and in silico analysis, highlighting four significant residues for vaccine design.

The G57 genotype of the BJ/94-like H9N2 lineage exhibits increased replication and virulence in chickens compared to the G1 Middle East Group B lineage

This study compares two H9N2 avian influenza lineages, finding the G57 genotype has higher replication, virulence, and transmission fitness in chickens than the G1-B lineage.

The Haemagglutinin Gene of Bovine Origin H5N1 Influenza Viruses Currently Retains an Avian Influenza Virus phenotype.

Haemagglutinin of US cattle and goat H5N1 binds only avian-type receptors and fuses at pH 5.9; seven emerging cattle mutations did not switch receptor preference.

Immunisation of chickens with inactivated and/or infectious H9N2 avian influenza virus leads to differential immune B cell repertoire development

This study examines how different vaccination and infection regimes in chickens affect their H9N2-specific IgM and IgY antibody repertoires, revealing public and private clonal responses.

The Haemagglutinin Genes of the UK Clade 2.3.4.4b H5N1 Avian Influenza Viruses from 2020 to 2022 Retain Strong Avian Phenotype

This study evaluates HA functionality of UK H5N1 avian influenza viruses from 2020-2022, finding they retain strong avian phenotype with low zoonotic threat.