Author

Yu Guo

Johns Hopkins UniversityORCID 0000-0002-6802-0708Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Michael D. KornbergiD· 2 shared Paul M. KimiD· 2 shared Shruthi ShanmukhaiD· 2 shared Wesley H. GodfreyiD· 2 shared Xiaojing Deng· 2 shared Efrat AbramsoniD· 1 shared Jeffrey K. HuangiD· 1 shared Jingwen HuiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Michael D. KornbergORCID

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2 papers

Recent·Most cited

TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis

Shruthi Shanmukha, Wesley H. Godfrey, Payam Gharibani, Judy J. Lee, Yu Guo, Xiaojing Deng, Paul A. Wender, Michael D. Kornberg, Paul M. Kim

This study shows TPPB, a new PKC modulator, reduces neuroinflammation and promotes CNS repair in experimental MS by targeting innate immune cells.

bioRxiv · Feb 2, 2024Immunology

PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination

Payam Mohammad Gharibani, Efrat Abramson, Shruthi Shanmukha, Matthew D. Smith, Wesley H. Godfrey, Judy J. Lee, Jingwen Hu, Maryna Baydyuk, Marie‐France Dorion, Xiaojing Deng, Yu Guo, Soonmyung A. Hwang, Jeffrey K. Huang, Peter A. Calabresi, Michael D. Kornberg, Paul M. Kim

The paper shows that bryostatin-1, a PKC modulator, shifts microglia and CNS macrophages from pro-inflammatory to regenerative states, promoting remyelination and neuroprotection in MS.

bioRxiv · Aug 28, 2023 · PreprintNeuroscience