Sarvind Mani Tripathi

Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein (Rb) pocket domain

This study analyzes how cancer-associated missense variants in Rb's pocket domain affect its binding and stability using biophysical assays and crystallography.

Regulation of the circadian clock in C. elegans by clock gene homologs kin-20 and lin-42

This study investigates the role of lin-42 and kin-20 in the circadian clock of C. elegans using a bioluminescence reporter, showing they regulate the period length through neuronal cells.

The MuvB Complex Binds and Stabilizes Nucleosomes Downstream of the Transcription Start Site of Cell-Cycle Dependent Genes

This study determines the structure of the MuvB complex and shows it binds and stabilizes nucleosomes downstream of the transcription start site to repress gene expression.

A Long Lost Key Opens an Ancient Lock: Drosophila Myb Causes a Synthetic Multivulval Phenotype in Nematodes

This paper shows that Drosophila Myb can bind to nematode LIN9 and LIN52 proteins and cause a synthetic multivulval phenotype in C. elegans, despite their distant evolutionary divergence.