Boyan Bonev

Post-translational Tuning of Human Cortical Progenitor Neuronal Output

The paper identifies phosphorylation of NEUROGENIN2 as a regulator of human radial glial cell neuronal output, leading to increased production of upper-layer neurons.

Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis

The paper integrates single-cell transcriptomics and epigenomics to show how neural stem cells shift lineage bias and epigenetic states during mouse corticogenesis.

Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolution

This study identifies human-specific morphoregulatory signatures in basal radial glia that drive neocortex evolution through comparative chromatin and transcriptional profiling.

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development

The paper maps 3D genome organization, chromatin accessibility, and gene expression in primate neural stem cells to identify human-specific epigenetic signatures and their role in gene regulation.

Context-dependent epigenome rewiring during neuronal differentiation

The paper investigates how cellular and epigenetic contexts influence Neurog2 binding and its functional consequences in mouse embryonic stem cells and neural progenitor cells, revealing cell-type-specific chromatin accessibility and interactors.

The glucocorticoid receptor as a master regulator of Mueller cell gliosis in the diabetic retina

The paper identifies the glucocorticoid receptor as a master regulator of Muller cell gliosis in diabetic retinopathy and shows that increasing GR expression can improve retinal function.

Multiomics analysis reveals extensive epigenome remodeling during cortical development

The paper uses multiomics data to map regulatory changes in the mouse neocortex during development, identifying novel enhancer-gene pairs and epigenetic remodeling patterns.