Adam E. Cohen

This paper shows that membrane tension propagates along axons at 20 micrometers per second, influencing axon growth and branching through mechanical signaling.

The paper shows that specific dendritic branches in cortical layer 2/3 pyramidal cells fail to evoke calcium influx from bAPs due to branch-specific properties, despite having functional VGCCs.

The paper uses voltage imaging to identify spinal circuits in zebrafish that modulate locomotor adaptation by characterizing a novel sub-population of V3 neurons.

The paper introduces improved genetically encoded voltage indicators for all-optical electrophysiology, revealing interneuron network dynamics in live mice.

Genetically encoded voltage imaging reveals presynaptic neuronal activity drives focal astrocyte depolarization, inhibiting glutamate uptake during neuronal activity.

The paper develops a novel genetically encoded voltage indicator, NovArch, enabling high-resolution voltage imaging in brain tissue with improved sensitivity, background rejection, and time resolution.

This paper introduces a method to accurately estimate spikes and subthreshold waveforms from 1-photon voltage imaging in vivo, even with noise.

All-optical electrophysiology in awake mice reveals inhibitory microcircuit function in barrel cortex Layer 1 by combining voltage recording with optogenetic manipulation.

The paper develops all-optical electrophysiology tools to record subthreshold dynamics and excitability in mouse hippocampus during behavior, revealing brain-state dependent changes in neuronal activity.

The paper develops tools for wide-area mapping of neuronal activity in brain slices using optimized optogenetic tools and structured illumination.

The paper introduces an all-optical electrophysiology method called Optopatch to functionally characterize human iPSC-derived motor neurons in ALS models, finding altered electrophysiological properties in SOD1 A4V mutants.